| Description |
1 online resource (577 pages) |
| Series |
Lung Biology in Health and Disease |
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Lung biology in health and disease.
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| Contents |
FRONT COVER; INTRODUCTION; FOREWORD; PREFACE; CONTRIBUTORS; CONTENTS; Chapter 1. Introduction; Chapter 2. Serum IgE Distributions in Normal and Asthmatic Subjects; Chapter 3. Understanding the Binding of IgE to Its High-Affnity Receptor and to an Anti-IgE Antibody; Chapter 4. Mediator Release from Basophils and Mast Cells and Its Relationship to Fcepsilon RI Expression and IgE-Suppressing Therapies; Chapter 5. Expression of IgE Receptors on Eosinophils; Chapter 6. Eosinophil IgE Receptors Controversy and Consensus |
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Chapter 7. Murine Models of Asthma Caveats and Conclusions on the Contribution of IgE and Mast Cells to Allergic In.ammation, Airway Hyperresponsiveness, and Air.ow ObstructionChapter 8. Role of IgE in Asthma Pathogenesis and Novel Therapeutic Strategies; Chapter 9. IgE-Mediated Response to Allergen in the Bronchoprovocation Laboratory; Chapter 10. Pathophysiology of the Airway Response to Inhaled Allergen in Asthmatic Subjects Role of IgE; Chapter 11. Effcacy and Safety of Xolair Anti-IgE Monoclonal Antibody in Adult Asthmatics; Chapter 12. The Role of IgE in Pediatric Asthma |
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Chapter 13. Anti-inflammatory Activities of Omalizumab (Xolair), A Recombinant Humanized Monoclonal Antibody Binding IgEChapter 14. Pulmonary Delivery of Anti-IgE Rationale for Topical Delivery to the Airway; Chapter 15. Treatment of Seasonal Allergic Rhinitis; Chapter 16. Anti-IgE and Allergic Skin Diseases; Chapter 17. Role of IgE and Food Allergens; Chapter 18. Role of IgE in Allergic Bronchopulmonary Aspergillosis; Chapter 19. IgE and Its Role in Parasitic Helminth Infection Implications for Anti-IgE-Based Therapies; Chapter 20. The Rise of Antibodies as Therapeutics; AUTHOR INDEX |
| Summary |
Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express these receptors, and the functional activity of IgE-FceRI and IgE-FceRII interactions for improved control and management of allergic disorders.Compiles previously unpublished data from the first extensive scientific investigations of Xolair!IgE and |
| Notes |
Subject indexback cover |
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Print version record |
| Subject |
Anti-immunoglobulin E autoantibodies.
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Asthma.
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Immunoglobulin E.
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Asthma
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Immunoglobulin E
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Anti-immunoglobulin E autoantibodies
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Asthma
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Immunoglobulin E
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| Form |
Electronic book
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| ISBN |
9780203909003 |
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0203909003 |
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