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E-book

Title Cancer chemoprevention. Vol. 2, Strategies for cancer chemoprevention / edited by Gary J. Kelloff, Ernest T. Hawk and Caroline C. Sigman
Published Totowa, N.J. : Humana, 2005

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Description 1 online resource (xxi, 543 pages) : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Chemopreventive Agent Development Science -- Characterization of Natural Product Chemopreventive Agents -- Preclinical Animal Models for the Development of Cancer Chemoprevention Drugs -- Potential Use of Transgenic Mice in Chemoprevention Studies -- Modeling Human Colorectal Cancer in Mice for Chemoprevention Studies -- Pathology of Incipient Neoplasia -- Quantitative Nuclear Grade -- Enabling Discovery Through Online Cancer Genome Databases and Analytic Tools -- Functional Genomics for Identifying Surrogate Endpoint Biomarkers in Breast Cancer Chemoprevention -- Clinical Applications of Proteomics -- Bioinformatics and Whole-Genome Technologies -- Models of Absolute Risk -- Genetic Polymorphisms and Risk Assessment for Cancer Chemoprevention -- Design Issues in Prostate Cancer Chemoprevention Trials -- Recruitment Strategies for Cancer Prevention Trials -- Cancer Chemoprevention at Major Cancer Target Sites -- Prostate Cancer Prevention -- Use of PSA to Evaluate Risk and Progression of Prostate Cancer -- Clinical Approaches to Discovering and Testing New Breast Cancer Prevention Drugs -- Ductal Lavage -- Counteracting Estrogen as Breast Cancer Prevention -- Chemoprevention of Colorectal Cancer -- Screening in Risk Evaluation and Prevention of Colorectal Cancer -- Strategies in Lung Cancer Chemoprevention -- Lung Cancer Chemoprevention -- Bladder Cancer -- Barrett's Esophagus -- Endoscopic Detection of Esophageal Neoplasia -- Chemoprevention Strategies for Esophageal Squamous Cell Carcinoma -- Chemoprevention of Upper Aerodigestive Tract Cancer -- Chemoprevention of Oral Cancer -- Strategies in Skin Cancer Chemoprevention -- Opportunities and Challenges for Skin Cancer Chemoprevention -- Progress in Developing Effective Chemoprevention Agents for Cervical Neoplasia -- Immunoprevention of Cervical Cancer -- Objective Biomarkers in Endometrioid-Type Endometrial Carcinogenesis -- Epithelial Ovarian Cancer -- Strategies for Chemoprevention in Pancreatic Cancer -- Clinical Strategies for Chemoprevention of Liver Cancer -- Chemoprevention
Summary Annotation Leading researchers comprehensively describe the exciting methodologies that are accelerating progress in chemoprevention and review the state of clinical development of preventive agents in the major human cancer target organs. The authors provide sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design. The emphasis is on documenting the characterization and application of reliable biomarkers during chemopreventive drug development. Highlights include an elegant approach to identifying chemopreventive agents in natural products, the development of preclinical models for evaluating potential chemopreventive agents, and the genomics and proteomics of potential applications
Annotation These two volumes provide a comprehensive survey of promising cancer chemopreventive agents, grouped by pharmacological and or mechanistic classes. The agent classes vary widely in terms of their stage of development as chemo-preventatives, ranging from extensively covered groups such as nonsteroidal anti-inflamatories and anti-estrogens to drugs with recently identified potential based on mechanistic data such as protein kinase inhibitors. Provides a comprehensive survey of promising cancer chemopreventive agents, grouped by pharmacological and or mechanistic classes Describes considerations in discovery and drug development of chemopreventives This review will benefit scientists interested in developing drugs for disease prevention and cancer prevention
Annotation Leading researchers comprehensively describe the exciting methodologies that are accelerating progress in chemoprevention and review the state of clinical development of preventive agents in the major human cancer target organs. The authors provide sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design
Annotation These two important volumes provide both a comprehensive survey of promising cancer chemopreventive agents, and exciting methodologies that are accelerating progress in chemoprevention, reviewing the state of clinical development of preventive agents in the major human cancer target organs
Annotation Volume 2 provides sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design. The emphasis is on documenting the characterization and application of reliable biomarkers during chemopreventive drug development
Analysis geneeskunde
medicine
volksgezondheid
public health
oncologie
oncology
Medicine (General)
Geneeskunde (algemeen)
Subject Cancer -- Chemoprevention.
Drugs.
Anticarcinogenic Agents -- therapeutic use
Neoplasms -- prevention & control
Pharmaceutical Preparations
Chemoprevention -- methods
Cancer -- Chemoprevention
Drugs
Form Electronic book
Author Kelloff, Gary J
Hawk, Ernest T
Sigman, Caroline C
ISBN 9781592597680
1592597688
Other Titles Strategies for cancer chemoprevention