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Title Natriuretic peptides : the hormones of the heart / Aldo Clerico, Michele Emdin (eds.) ; foreword by Luigi Donato
Published Berlin : Springer, [2006]
©2006
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Description 1 online resource (xiv, 184 pages) : illustrations
Contents Cover -- Contents -- About the Authors -- Abbreviations -- 1 Historical Background and Book Aim -- 1.1 Historical Background -- 1.2 Book Aim and Plan -- 2 The Heart Complexity -- The Intrinsic Function (Intrinsic Regulation of Heart Rate and Mechanics) -- 2.1 Preamble -- 2.2 Heart Physiology: the Classical View -- 2.3 Neural Control of the Heart:Cardiac Receptors, Afferent/Efferent Neural Pathways, Baro- and Chemoreceptive Feedback -- 2.3.1 Premises on the Neuro-Humoral Control of the Cardiovascular System -- 2.3.2 Autonomic Control of Heart Rate -- 2.3.3 Afferent Stimuli -- 2.3.4 Efferent Neural Connections -- 2.3.5 Spinal Cord -- 2.3.6 Medullary Centers -- 2.3.7 Supramedullary Control -- 2.4 The Integrated Neuro-Hormonal Response: Short- and Long-Term Response -- 2.5 Heart Physiology:What is New? -- 3 The Cardiac Natriuretic Hormone System -- 3.1 Chemical Structure and Gene Evolution of Cardiac Natriuretic Hormones -- 3.2 Genes Encoding for Cardiac Natriuretic Hormones -- 3.3 Regulation of Production/Secretion of ANP and BNP in Cardiac Tissue -- 3.4 Biological Action of CNH -- 3.5 Natriuretic Peptide Receptors and Intracellular Second Messenger Signaling -- 3.5.1 Genes Encoding for NPRs -- 3.5.2 Biological Function of NPRs -- 3.6 Metabolic Pathways and Circulating Levels of CNH -- 3.6.1 ANP Metabolism -- 3.6.2 BNP Metabolism -- 3.7 CNH System in Fetal Heart and Circulation -- 3.8 CNH Genes and Cardiovascular Diseases -- 3.9 An Integrated Neuro-Hormonal System Regulates Vascular Function -- 3.10 Summary and Conclusion -- 4 Cardiac Natriuretic Hormones as Markers of Cardiovascular Disease: Methodological Aspects -- 4.1 General Considerations -- 4.2 Determination of ANP and NT-proANP -- 4.2.1 Competitive Immunoassay Methods for ANP -- 4.2.2 Non-Competitive Immunoassay Methods for ANP -- 4.2.3 Determination of NT-proANP -- 4.3 Determination of BNP and NT-proBNP -- 4.3.1 First-Generation (Manual) BNP Assays -- 4.3.2 Second-Generation (Automated) BNP Assays -- 4.3.3 Determination of NT-proBNP -- 4.3.4 Specificity of BNP/NT-proBNP Assays -- 4.3.5 Quality Specifications for BNP/NT-proBNP Assays -- 4.4 Determination of Other Natriuretic Peptides (CNP, DNP, and Urodilatin) -- 4.5 Summary and Perspectives -- 5 Clinical Considerations and Applications in Cardiac Diseases -- 5.1 Circulating Levels of Cardiac Natriuretic Hormones: Physiological Considerations and Clinical Interpretation -- 5.1.1 Influence of Age and Gender -- 5.1.2 Comparison between the CNH Assay and that of CNH-Related Pro-Hormone Peptides -- 5.1.3 Resistance to the Biological Action of CNH -- 5.1.4 Diagnostic Accuracy of CNH Assay in Plasma from Patients with Cardiac Diseases -- 5.1.5 Biological Variation of Plasma BNP: a Problem or a Clinical Resource? -- 5.2 CNH Assay as Diagnostic and Prognostic Tool in Cardiac Diseases -- 5.2.1 Use of CNH Assay in the Screening and Classification of Patients with Cardiac Dysfunction -- 5.2.2 Diagnostic Accuracy of CNH Assay in Asymptomatic, Mild Ventricular Systolic Dysfunction -- 5.2.3 Diagnostic
Summary The rapid knowledge in the field of neuro-humoral regulation of cardiovascular pathophysiology is changing the picture of current diagnosis and treatment of cardiac patients. The emerging conceptual revolutionary idea is that heart acts not as a pump, merely, but as a ""gland"", that is as a regulator of circulatory homeostasis and salt-water balance. Cardiovascular pathophysiology has to be written, indeed, on this basis: this physiology textbook gives an up-to-date description of the complexity and novelty of actual knowledge, with all its potential clinical implications
Bibliography Includes bibliographical references
Notes Print version record
Subject Atrial natriuretic peptides.
Form Electronic book
Author Clerico, Aldo.
Emdin, Michele.
LC no. 2006924126
ISBN 8847004977
8847004985
9788847004979
9788847004986