| Description |
vii, 159 pages : illustrations (some color) ; 26 cm |
| Series |
Annals of the New York Academy of Sciences, 0077-8923 ; v. 1277 |
|
Annals of the New York Academy of Sciences ; v. 1277. 0077-8923
|
| Contents |
Introduction to Antimicrobial therapeutics reviews : the bacterial cell wall as an antimicrobial target / Karen Bush -- Recent trends in resistance to cell envelope-active antibacterial agents among key bacterial pathogens / Ronald N. Master ... [et al.] -- The physiology of bacterial cell division / Alexander J.F. Egan and Waldemar Vollmer -- Viable screening targets related to the bacterial cell wall / Lynn L. Silver -- Bacterial cell-wall recycling / Jarrod W. Johnson, Jed F. Fisher, and Shahriar Mobashery -- [beta]-Lactam antimicrobials : what have you done for me lately? / George H. Talbot -- Proliferation and significance of clinically relevant [beta]-lactamases / Karen Bush -- Metallo-[beta]-lactamase structure and function / Timothy Palzkill -- New [beta]-lactam-[beta]-lactamase inhibitor combinations in clinical development / David M. Shlaes -- Siderophore conjugates / Malcolm G.P. Page -- Peptide antimicrobials : cell wall as a bacterial target / Nannette Y. Yount and Michael R. Yeaman -- Mechanisms of daptomycin resistance in Staphylococcus aureus : role of the cell membrane and cell wall / Arnold S. Bayer, Tanja Schneider, and Hans-Georg Sahl |
| Summary |
"Bacterial cell walls are unique structures that serve as ideal targets for antimicrobial drugs. Agents that interfere with bacterial cell wall biosynthesis or cell integrity have been used therapeutically with high efficacy and good safety since the 1940s. Because there is no comparable structure in mammalians, bacterial cell wall inhibitors can exhibit high target specificity with side effect profiles that are not target related, unlike some other classes of antibiotics. In addition, cell wall--active agents are frequently bactericidal in their action, providing the opportunity for complete bacterial clearance in serious infections. In this Annals volume, the contributors explore the various roles of the bacterial cell wall as related to the physiology of bacteria and to the development of antibacterial drugs."--Publisher's description |
| Notes |
Caption title |
| Bibliography |
Includes bibliographical references |
| Subject |
Anti-infective agents.
|
|
Antibiotics.
|
|
Bacterial cell walls -- Synthesis -- Inhibitors.
|
| Author |
Bush, Karen (Biologist)
|
| LC no. |
2013427286 |
| ISBN |
9781573318792 |
|
1573318795 |
|
