| Description |
1 online resource (297 pages) |
| Contents |
Intro -- Preface -- Contents -- Contributors -- Editor Biographies -- Chapter 1: Epidemiology and Risk Factors of Basal Cell Carcinoma -- Epidemiology -- Introduction -- Geography -- Demographics -- Location and Histologic Subtype -- Morbidity and Mortality -- Economic Burden -- Prevention -- Risk Factors -- Introduction -- UV Radiation -- Photosensitizing Medications -- Ionizing Radiation -- Chemical Exposures -- Immunosuppression -- Genes -- Conclusion -- References -- Chapter 2: Pathophysiology of Basal Cell Carcinoma and Its Associated Genetic Syndromes -- Introduction |
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Basal Cell Nevus Syndrome (BCNS) -- Bazex-Dupre-Christol Syndrome -- Rombo Syndrome -- Additional Genetic Syndromes with Increased Risk of Basal Cell Carcinoma -- References -- Chapter 3: Histopathology of Basal Cell Carcinoma and Its Variants -- Introduction -- Common Histologic Features -- Histologic Variants -- Nodular Basal Cell Carcinoma -- Superficial Basal Cell Carcinoma -- Infundibulocystic/Hamartomatous Basal Cell Carcinoma -- Fibroepithelioma of Pinkus -- Infiltrative Basal Cell Carcinoma -- Morpheaform Basal Cell Carcinoma -- Micronodular Basal Cell Carcinoma |
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Clear Cell Basal Cell Carcinoma -- Adenoid Basal Cell Carcinoma -- Pleomorphic Basal Cell Carcinoma -- Keratotic Basal Cell Carcinoma -- Basal Cell Carcinoma with Matrical Differentiation -- Basal Cell Carcinoma with Ductal Differentiation -- Metaplastic Basal Cell Carcinoma -- High-Risk Features -- References -- Chapter 4: Topical Therapy for the Treatment of Basal Cell Carcinoma -- Introduction -- Background -- Mechanism of Action -- Imiquimod -- 5-Fluorouracil -- Ingenol Mebutate -- Efficacy -- Imiquimod -- 5-Fluorouracil -- Ingenol Mebutate -- Safety -- Imiquimod -- 5-Fluorouracil |
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Ingenol Mebutate -- Comparative Studies -- Imiquimod -- Comparison of Different Treatment Regimens of Imiquimod to Vehicle Cream -- Comparison of Imiquimod to Other Treatment Modalities -- 5-Fluorouracil -- Ingenol Mebutate -- Emerging Topical Treatments and Combination Therapies -- Combination Therapies -- Imiquimod Plus CT -- Imiquimod Plus PDT -- Imiquimod Plus Curettage -- Imiquimod Plus MMS -- 5-FU Combination Therapy -- Discussion and Conclusions -- References -- Chapter 5: Local Immunotherapy for Basal Cell Carcinoma with Interferon -- Introduction -- Background |
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Role of the Immune System -- Treatment with Immunostimulatory Agents (ISRX) -- Efficacy -- Low Recurrence Rate -- Normal Skin Markings -- Cosmesis -- Preservation of Function -- No Wound -- All Other Therapeutic Options Remain Open -- Disadvantages of ISRX -- Mechanism of Action of ISRX -- Patient/Tumor Selection -- Interferon Injections -- Preparation of IFN for Injection -- Injection Technique -- Dosage of IFN -- Combination of IFN with IMIQ -- Side Effects -- Recommended Follow-Up for BCC Treated with ISRX -- Conclusion -- References |
| Summary |
Basal Cell Carcinoma: Advances in Treatment and Research, edited and written by leaders with expertise in cutaneous oncology, dermatopathology, dermatology, Mohs micrographic surgery, head and neck surgery, oculoplastic surgery and radiation oncology, provides a comprehensive overview of evidence-based treatment approaches for the most common cancer worldwide - basal cell carcinoma. The first part of this book details the epidemiology, risk factors, pathophysiology, and different histologic subtypes of basal cell carcinoma highlighted with high-resolution histopathology images. The second part of the book provides an in-depth review of different treatment modalities including topical therapy, local immunotherapy with interferon, cryotherapy, electrodesiccation and curettage, radiotherapy, and surgical approaches with Mohs micrographic surgery, head and neck surgery, and oculoplastic surgery. The final part of book highlights the utilization of innovative technology such as photodynamic therapy and laser for the treatment of basal cell carcinoma as well as emerging systemic therapeutic options including hedgehog pathway inhibitors and immunotherapy for the difficult-to-treat disease state, advanced basal cell carcinoma. Meant for a multi-disciplinary audience of dermatologists, Mohs Surgeons, oncologists, head and neck surgeons, oculoplastic surgeons, radiation oncologists, this book serves as an informative practical guide for physicians, mid-level providers and trainees |
| Notes |
Chapter 6: Cryotherapy and Electrodesiccation & Curettage for Basal Cell Carcinoma |
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Includes index |
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Print version record |
| Subject |
Basal cell carcinoma.
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Carcinoma, Basal Cell
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Basal cell carcinoma
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| Form |
Electronic book
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| Author |
Migden, Michael R.
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Chen, Leon
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Silapunt, Sirunya.
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| ISBN |
9783030268879 |
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303026887X |
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