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Author Bodensee Symposium on Microcirculation (17th : 2002 : Lindau, Bavaria, Germany)

Title Microcirculatory effects of hemoglobin solutions / 17th Bodensee Symposium on Microcirculation, Lindau, June 21-23, 2002 ; volume editors, K. Messmer, K.E. Burhop, J. Hutter
Published Basel ; New York : Karger, [2004]
©2004
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Description 1 online resource (x, 106 pages) : illustrations (some color)
Series Progress in applied microcirculation, 0254-5195 ; v. 25
Progress in applied microcirculation ; v. 25. 0254-5195
Summary Solutions of stroma-free hemoglobin have been investigated for their potential as blood replacement fluids for more than 70 years. Despite many attempts to overcome their unwanted side effects through chemical modification of the hemoglobin molecule, none of the potential solutions has been approved for clinical use in Europe or the United States.In recent years, the vasoconstrictive activity of hemoglobin in the plasma was identified as the pivotal problem of hemoglobin-based blood substitutes, compromising nutritional perfusion and thus impeding oxygen unloading at the site of the microcirculation. One of the prevailing assumptions is that the precapillary vasoconstriction and the ensuing tissue underperfusion is caused by the high affinity of free hemoglobin for nitric oxide. To resolve this problem, a number of recombinant techniques involving site-directed mutagenesis as well as several chemical approaches involving polymerization and pegylation have been developed.This volume summarizes the latest research on the effects of some of these new hemoglobin solutions on the microvasculature and tissue oxygenation. It is recommended reading for all those interested in finding alternatives for donor blood in transfusion medicine, including emergency specialists, anesthesiologists, surgeons, trauma surgeons and other clinicians who are frequently confronted with blood loss and the need for blood replacement
Bibliography Includes bibliographical references and indexes
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
digitized 2010 HathiTrust Digital Library committed to preserve pda MiAaHDL
Print version record
Subject Blood Substitutes -- adverse effects.
Blood Substitutes -- pharmacokinetics.
Blood Substitutes -- therapeutic use.
Hemoglobins -- adverse effects.
Hemoglobins -- pharmacokinetics.
Hemoglobins -- therapeutic use.
Microcirculation.
Blood substitutes -- Congresses.
Hemoglobin -- Therapeutic use -- Congresses.
Microcirculation -- Congresses.
Genre/Form Congress.
Conference papers and proceedings.
Conference papers and proceedings.
Form Electronic book
Author Burhop, K. E.
Hutter, J.
Messmer, K.
ISBN 3318010685
9783318010688
(hard cover)
(hard cover)