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Title Bone and cancer / Felix Bronner, Mary C. Farach-Carson, (eds.)
Published London : Springer, [2009]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (xviii, 264 pages) : illustrations (some color)
Series Topics in bone biology ; v. 5
Topics in bone biology ; v. 5
Contents Blood-bone axis and bone marrow microenvironment -- Genetics of osteosarcoma -- Multiple myeloma and other hematological malignancies of bone -- Mechanisms of metastasis to bone: the role of bone marrow endothelium -- Lysophosphatidic acid: role in bone and bone cancer -- Role of bone microenvironment/metastatic niche in cancer progression -- Detection and characterization of disseminated tumor cells present in bone marrow of cancer patients -- Molecular imaging of cancer cells growing in bone -- Inflammatory cytokines and their role in bone metastasis and osteolysis -- Prostate cancer bone colonization: osteomimicry in the bone niche -- Bone pain associated with cancer metastasis -- Small animal models for the study of cancer in bone -- Hormonal therapies in breast and prostate cancer: effects on bone and the role of bisphosphonates -- Therapeutic approaches to metastatic bone cancer II: targeted and non-targeted systemic agents -- The role of allogeneic bone marrow transplant in cancer treatment -- The role of radiosurgery in the treatment of bone localized cancers
Summary This book features current knowledge concerning mechanisms of metastasis, the role of the bone microenvironment in cancer progression, function of inflammatory cytokines in metastasis and osteolysis, the role of osteoblasts, thus offering cellular and molecular findings that affect the search for drugs and lead to translational studies. In addition, it contains chapters on animal models for cancer, the molecular imaging of cancer cells, and bone marrow transplants. There are also chapters on bone pain and current therapeutic approaches to secondary bone cancer (i.e. the use of bisphosphonates, chemotherapy, hormone therapy), of particular relevance to the clinician. Each chapter contains extensive bibliography, tables, diagrams and figures that clarify the skeletal complications in the cellular events that lead to cancer development and progression of disease in bone. Chapters tie insights stemming from molecular and cellular events to the clinical picture, focusing on translation of discoveries in the laboratory to the clinic which helps clinicians better understand the basis of a particular event and basic scientists to appreciate the potential importance of their research. With chapters written by authorities in the field, the book is of interest to academic clinicians, researchers of bone and bone cancers, professional staff of hospitals and pharmaceutical houses, and personnel involved in, and concerned with, cancer care and therapy
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Bone metastasis.
Bone Neoplasms.
Neoplasm Metastasis.
Form Electronic book
Author Bronner, Felix.
Farach-Carson, Mary C., 1958-
LC no. 2008942781
ISBN 1848820194 (e-isbn)
9781848820197 (e-isbn)