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Book Cover
E-book

Title Bone metastasis : experimental and clinical therapeutics / edited by Gurmit Singh, Shafaat A. Rabbani
Published Totowa, N.J. : Humana Press, [2005]
©2005
Online access available from:
Springer eBooks    View Resource Record  

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Description 1 online resource (xiii, 344 pages) : illustrations
Series Cancer drug discovery and development
Cancer drug discovery and development.
Contents Antithrombotics in tumor growth and metastasis / Shaker A. Mousa -- Challenges and strategies in the analysis of multiple events in oncology / Pierre P. Major and Richard J. Cook -- Integrins : novel targets for the treatment of bone metastasis / Graham C. Parry [and others] -- Bone metastasis and pathological fractures : bone tissue engineering as a novel therapy / Laurie A. McDuffee, Nigel Colterjohn, and Gurmit Singh -- Role of photodynamic therapy for bone metastasis / Shane Burch and Albert J.M. Yee -- Docetaxel for metastatic cancer and its role in combination therapies for advanced prostate cancer / Ellen K. Wasan [and others] -- The use of tetracyclines for bone metastasis / Eric Seidlitz, Zeina Saikali, and Gurmit Singh -- Role of bisphosphonates in skeletal metastases / Arif Hussain and Fred Saad -- Radiation treatment of bone metastases / Edward Chow, Jackson Wu, and Elizabeth Toni Barnes
Overview / Sadmeet Singh and Gurmit Singh -- Parathyroid hormone-related peptide and malignancy / David Goltzman -- Vitamin D and vitamin D analogs in cancer / Richard Kremer and Shafaat A. Rabbani -- Role of TGF and IGF in tumor progression and bone metastases / Erin Giles and Gurmit Singh -- Biologic and therapeutic implications of osteomimicry and epithelial/mesenchymal transition in prostate cancer / Wen-Chin Huang, Valerie Odero-Marah, and Leland W.K. Chung -- The roles of immune-cell derived matrix metalloproteinases in tumor growth and metastasis / Kristina A. Szabo and Gurmit Singh -- Contribution of osteopontin to the development of bone metastasis / Alison L. Allan [and others] -- The role of interleukin-11 in osteolytic bone metastasis / Ryan R. Simon [and others] -- Cell adhesion moleculars in tumor metastasis / Sujata Persad [and others]
Summary This book gives a state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage
Bibliography Includes bibliographical references and index
Notes Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL
Print version record
Subject Bone metastasis.
Bone Neoplasms -- secondary.
Neoplasm Metastasis.
Form Electronic book
Author Rabbani, Shafaat A.
Singh, Gurmit.
LC no. 2004014785
ISBN 158829403X (hardcover ; alk. paper)
1592598927 (e-ISBN)
9781588294036 (hardcover ; alk. paper)
9781592598922 (e-ISBN)