| Description |
1 online resource |
| Series |
CISM International Centre for mechanical series. Courses and lectures ; volume 578 |
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Courses and lectures ; no. 578
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| Contents |
Preface; Contents; Contributors; Functional Adaptation of Bone: The Mechanostat and Beyond; 1 Introduction; 2 Functional Adaptation: Origins and Evolution of the Mechanostat and Its Physiological Properties; 2.1 Why Should Bones Respond to Exercise?; 2.2 What Happens When Bones Respond to Exercise or a Lack of It?; 2.3 Wolff's Law and the Mechanostat; 2.4 What Initiates and Controls Bone's Adaptive Response?; 2.5 Cellular and Molecular Machinery of the Mechanostat; 3 Animal Models for Structural Adaptations to Mechanical Loading; 3.1 Physiological Models |
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3.2 Externally Applied Loading Models3.3 Surgical Approaches; 3.4 Non-invasive Approaches; 4 Bone Cell Responses to Loading: Involved Regulatory Factors, Receptors and Environmental Factors; 4.1 Early Responses: ATP, Calcium, PGE2, Nitric Oxide; 4.2 Oestrogen Receptor Involvement in Load Sensing; 4.3 Intermediate Responses: RANKL and Wnt; 4.4 Sclerostin as a Master Regulator of Mechanical Loading; 5 Loading Physiology: Translating Findings from Animal Models to Clinical Applications in Humans; 5.1 Changes of Bone Mass with Age; 5.2 Effective Loading Characteristics |
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5.3 Translating Controlled Loading to Physical Activity5.4 Maximising Bone Strength; 5.5 Persistence of Childhood Bone Adaptation; 6 In Silico Models of Bone Adaptation; 6.1 Cowin's Theory of Adaptive Elasticity; 6.2 Stanford Model of Daily Stress Stimulus; 6.3 Huiskes' Strain Energy Density Model; 6.4 Turner's Model of Dynamic Loading Stimulus; 6.5 Recent Theories of Bone Adaptation; 7 Conclusion; References; Application of Disease System Analysis to Osteoporosis: From Temporal to Spatio-Temporal Assessment of Disease Progression and Intervention; 1 Introduction |
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2 Relationship Between Structure and Function of Bone: An Overview2.1 Bone Structure and Function; 2.2 Bone Physiology; 3 Biomarkers Characterising Mass, Quality and Turnover of Bone; 3.1 Bone Structure and Bone Mineral Density; 3.2 Bone Turnover Markers; 3.3 Characteristic Time Scale and Variability of Bone Biomarkers; 4 Bone Pathology: Osteoporosis and Treatments; 4.1 RANK-RANKL-OPG Pathway; 4.2 Risk Factors for Osteoporosis and Osteoporotic Fractures; 4.3 Current Diagnosis of Osteoporosis and Whole Bone Strength; 4.4 Current and Emerging Treatments; 5 Basics of Disease System Analysis |
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5.1 PK/PD Modelling5.2 Disease Progression Analysis; 6 Disease System Analysis of Osteoporosis; 6.1 Denosumab PK Model; 6.2 Mechanistic PK/PD Model of Osteoporosis; 6.3 Modelling Disease Progression in PMO; 6.4 Modelling the Action of Denosumab; 6.5 Numerical Simulations; 7 Summary and Conclusions; References; 3 Musculoskeletal Modelling and the Physiome Project; 1 The Physiome Project; 1.1 Introduction; 1.2 History of the Physiome Project; 1.3 Objectives of the Physiome Project; 1.4 Recent Developments and Future Directions for the Physiome Project; 2 Geometrical Musculoskeletal Modelling |
| Summary |
"The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations"-- Provided by publisher |
| Bibliography |
Includes bibliographical references |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed June 26, 2017) |
| Subject |
Bone remodeling.
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Bones -- Mechanical properties.
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Bone Remodeling
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Materials science.
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Orthopaedics & fractures.
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Mechanics of solids.
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MEDICAL -- Physiology.
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SCIENCE -- Life Sciences -- Human Anatomy & Physiology.
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Bone remodeling
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Bones -- Mechanical properties
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| Form |
Electronic book
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| Author |
Pivonka, Peter, editor
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| ISBN |
9783319588452 |
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3319588451 |
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