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Book Cover
Author Sultana, Naznin.

Title Biodegradable Polymer-Based Scaffolds for Bone Tissue Engineering
Published Dordrecht : Springer, 2013
Online access available from:
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Description 1 online resource (70 pages)
Series SpringerBriefs in Applied Sciences and Technology
SpringerBriefs in applied sciences and technology.
Contents Biodegradable Polymer-Based Scaffolds for Bone Tissue Engineering; Preface; Contents; 1 Scaffolds for Tissue Engineering; 1.1 Tissue Engineering; 1.2 Replacement and Regeneration of Bones; 1.2.1 Bone Structure and Composition; 1.2.2 Mechanical Properties of Bone; 1.2.3 Existing Approaches for Bone Replacement and Regeneration; 1.2.4 Needs for Bone Tissue Engineering; 1.3 Requirements for Scaffolds for Bone Tissue Engineering; 1.3.1 Surface Properties; 1.3.2 Physical Properties; 1.3.3 Mechanical Properties; 1.3.4 Degradation Properties; 1.3.5 Sterilizability
1.4 Candidate Biomaterials for Tissue Engineering Scaffolds1.4.1 Biopolymers; Poly(hydroxybutyrate) Polymer and Poly(hydroxybutyrate-co-hydroxyvalerate) Copolymer; PHB and PHBV Synthesis; Physical, Mechanical and Miscellaneous Properties of PHB and PHBV; Biodegradation of PHB and its Copolymers; 1.4.2 Inorganic Materials; 1.4.3 Biodegradable Polymer Blends; 1.4.4 Composites; References; 2 Fabrication Techniques and Properties of Scaffolds; 2.1 Scaffold Fabrication Techniques; 2.1.1 Electrospinning; 2.1.2 Solvent Casting and Particulate Leaching
2.1.3 Polymer Phase Separation2.1.4 Rapid Prototyping; 2.1.5 Polymer-Ceramic Composite Foams; 2.1.6 Melt Molding; 2.1.7 Gas Foaming; 2.1.8 Emulsion FreezingFreeze-Drying Technique; 2.2 Surface Modification for Bone Tissue Engineering Scaffolds; 2.3 Protein Adsorption; 2.4 In Vitro Degradation of Scaffolds; 2.4.1 Material and Medium Factors Affecting Degradation; 2.4.2 General Mechanism of Degradation; 2.4.3 Kinetics of Degradation; 2.4.4 Degradation Characteristics; Polymer Morphology; Polymer Composition; Molecular Weight; Additives; Others
2.5 Degradation of PLLA and PHB Polymers2.6 Diffusion Phenomena; 2.6.1 Factors Affecting Diffusion Phenomena; 2.6.2 Fickian and Non-Fickian Diffusion in Polymeric Materials; 2.7 In Vitro Biological Assessment; 2.7.1 Cell Culture; 2.7.2 Alkaline Phosphatase Assay; References; 3 Biodegradable PHBV Polymer-Based Scaffolds for Bone Tissue Engineering; 3.1 Fabrication of Biodegradable Polymer Scaffolds Using Emulsion FreezingFreeze-Drying Technique; 3.2 PolymerCeramic Composite Scaffolds and Characteristics of the Scaffolds; 3.3 In Vitro Degradation of PHBV and HAPHBV Scaffolds
3.4 Surface Modification and In Vitro Biological Evaluation of the ScaffoldsReferences; Summary; Index
Summary This book addresses the principles, methods and applications of biodegradable polymer based scaffolds for bone tissue engineering. The general principle of bone tissue engineering is reviewed and the traditional and novel scaffolding materials, their properties and scaffold fabrication techniques are explored. By acting as temporary synthetic extracellular matrices for cell accommodation, proliferation, and differentiation, scaffolds play a pivotal role in tissue engineering. This book does not only provide the comprehensive summary of the current trends in scaffolding design but also presents
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Tissue scaffolds.
Polymers -- chemistry.
Tissue Scaffolds -- chemistry.
Bone Substitutes -- chemistry.
Surface Properties.
Form Electronic book
ISBN 3642348025 (electronic bk.)
9783642348020 (electronic bk.)