Botulinustoxin. : Treatments from toxins : the therapeutic potential of clostridial neurotoxins / edited by Keith A. Foster, Peter Hambleton, Clifford C. Shone
Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
A disease caused by potent protein NEUROTOXINS produced by CLOSTRIDIUM BOTULINUM which interfere with the presynaptic release of ACETYLCHOLINE at the NEUROMUSCULAR JUNCTION. Clinical features include abdominal pain, vomiting, acute PARALYSIS (including respiratory paralysis), blurred vision, and DIPLOPIA. Botulism may be classified into several subtypes (e.g., food-borne, infant, wound, and others). (From Adams et al., Principles of Neurology, 6th ed, p1208)
Boucher, François, 1703-1770. : François Boucher : [catalogue of an exhibition at] Wildenstein, November 12 - December 19, 1980
1980
1
Droughts -- France -- Bouches-du-Rhône : Firefighters. Episode 3, Pressure is rising / RMC Découverte, Saint Thomas Productions present ; a film by Jacques Bedel, Sacha Bollet, Benoit Demarle ; written by Sacha Bollet, Benoit Demarle, Jacques Bedel ; proposed and produced by Bertrand Loyer
Forest fires -- France -- Bouches-du-Rhône -- History : Firefighters. Episode 5, Historic fire / RMC Découverte, Saint Thomas Productions present ; a film by Jacques Bedel, Sacha Bollet, Benoit Demarle ; written by Sacha Bollet, Benoit Demarle, Jacques Bedel ; proposed and produced by Bertrand Loyer
2020
1
Forest reserves -- Fire management -- France -- Bouches-du-Rhône : Firefighters. Episode 6, Calanques in danger / RMC Découverte, Saint Thomas Productions present ; a film by Jacques Bedel, Sacha Bollet, Benoit Demarle ; written by Sacha Bollet, Benoit Demarle, Jacques Bedel ; proposed and produced by Bertrand Loyer
