| Description |
1 online resource |
| Contents |
Spatial and temporal regulation of Ca2+ channels -- Neuronal functions of auxiliary calcium channel subunits.- Reciprocal regulation of neuronal calcium channels by synaptic proteins -- Molecular architecture of Ca2+ channel complexes organized by? subunits in presynaptic active zones -- Control of CaV2 calcium channels and neurosecretion by heterotrimeric G protein coupled receptors -- Regulation of CaV2 channels by small GTPases -- Protein interaction partners of Cav2.3 R-type voltage-gated calcium channels -- Voltage-gated calcium channel signaling to the nucleus -- Presynaptic Ca2+ influx and its modulation at auditory calyceal terminals -- Use of synthetic Ca2+ channel peptides to study presynaptic function -- Impact of a loss-of-function P/Q type Ca2+ channel mutation on excitatory synaptic control of cerebellar Purkinje neurons -- CaV2.1 (P/Q) voltage activated Ca2+ channels and synaptic transmission in genetic and autoimmune diseases -- Splicing and editing to customize CaV channel structures for optimal neural function -- Presynaptic calcium channels as drug targets for pain -- Sensory pathway modulation by calcium channel a2d1 subunit |
| Summary |
This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels. Importantly, Ca2+ channels represent one of the most widely modulated proteins in the body, being the target of a range of effector pathways and drugs; this range will be fully represented here. A number of therapeutic drugs target the Ca2+ channel complex, including the anti-epileptic gabapentinoid and analgesic ziconotide drugs and the pharmaceutical industry is searching for Ca2+ channel blocking drugs, particularly in th |
| Analysis |
Medicine |
|
Cytology |
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Cell membranes |
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Neurobiology |
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Biomedicine |
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Membrane Biology |
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Cell Physiology |
| Notes |
Includes index |
| Bibliography |
Includes bibliographical references and index |
| Notes |
English |
| In |
Springer eBooks |
| Subject |
Calcium channels.
|
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Presynaptic receptors.
|
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Calcium Channels
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Receptors, Presynaptic
|
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SCIENCE -- Life Sciences -- Biochemistry.
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Calcium channels
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Presynaptic receptors
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| Form |
Electronic book
|
| Author |
Stephens, Gary.
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|
Mochida, Sumiko
|
| ISBN |
9789400763340 |
|
9400763344 |
|
9400763336 |
|
9789400763333 |
|
