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Title Pathologies of calcium channels / Norbert Weiss, Alexandra Koschak, editors
Published Heidelberg : Springer, 2014
Online access available from:
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Description 1 online resource (xviii, 731 pages) : illustrations (some color)
Contents 880-01 Part I. Pathologies of Voltage-Gated Calcium Channels -- Part II. Pathologies of Transient Receptor Potential Channels -- Part III. Pathologies of Ligand-Gated Calcium Channels
880-01/(S Part I. Pathologies of Voltage-Gated Calcium Channels -- Ca v 2.1 Channels and Migraine / Daniela Pietrobon -- Ataxia and CACNA1A : Episodic or Progressive? / Stephanie Schorge and Kinya Ishikawa -- Role of L-Type Ca 2+ Channels in Sensory Cells / Alexandra Koschak, Alexandra Pinggera, Klaus Schicker and Jörg Striessnig -- T-Type Calcium Channels and Epilepsy / Stuart M. Cain, Michael E. Hildebrand and Terrance P. Snutch -- The Involvement of Calcium Channel α 2 δ Subunits in Diseases and as a Therapeutic Target / Annette C. Dolphin -- T-Type Calcium Channels in Pain Neuronal Circuits / Amaury Francois, Anne Pizzoccaro, Sophie Laffray and Emmanuel Bourinet -- Ca v 1.1 Channel and Hypokalemic Periodic Paralysis / Emma Matthews and Michael G. Hanna -- Ca v 1.1 in Malignant Hyperthermia / Viktor Yarotskyy and Robert T. Dirksen -- Ryanodine Receptor 1 and Associated Pathologies / Julien Fauré, Joël Lunardi, Nicole Monnier and Isabelle Marty -- The Lambert-Eaton Myasthenic Syndrome / Paul W. Wirtz, Maarten J. Titulaer and Jan J.G.M. Verschuuren -- Alternative Exon Effect on Phenotype of Ca v 1.2 Channelopathy: Implications in Timothy Syndrome / Hua Huang, Juejin Wang and Tuck Wah Soong -- Brugada Syndrome and Voltage-Gated Calcium Channels / Brett Simms -- Ca v 1.3 Channels and Sino-Atrial Node Dysfunction / Pietro Mesirca and Matteo E. Mangoni -- Auxiliary β-Subunits of L-Type Ca 2+ Channels in Heart Failure / Jan Matthes and Stefan Herzig -- Epigenetic, Genetic, and Acquired Regulation of Ca v 3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression / Maria Beatrice Morelli, Sonia Liberati, Consuelo Amantini, Matteo Santoni [and 3 others] -- Pharmacology of Voltage-Gated Calcium Channels in Clinic / Lubica Lacinová and Lucia Lichvárová -- Part II. Pathologies of Transient Receptor Potential Channels -- TRPM1 and Congenital Stationary Night Blindness / Shoichi Irie and Takahisa Furukawa -- Alterations in TRPM2 and TRPM7 Functions in the Immune System Could Confer Susceptibility to Neurodegeneration / Meredith C. Hermosura -- TRPML Channels and Mucolipidosis Type IV / Christian Grimm and Math P. Cuajungco -- Transient Receptor Potential Channels and Pain / Alexandre Denadai-Souza and Nicolas Cenac -- Hereditary Channelopathies Caused by TRPV4 Mutations / Jeremy M. Sullivan, Thomas E. Lloyd and Charlotte J. Sumner -- TRPC Channels in Cardiac Hypertrophy / Nadine Kirschmer, Kristina Lorenz and Petra Eder-Negrin -- Role of TRPC and Orai Channels in Vascular Remodeling / Michael Poteser, Sarah Krenn and Klaus Groschner -- TRPP2 in Polycystic Kidney Disease / Andrew Streets and Albert Ong -- TRPM6 and Hypomagnesaemia/Hypocalcaemia / Daniel Landau and Hanna Shalev -- TRP Channels in Prostate Cancer / George Shapovalov, Roman Skryma and Natalia Prevarskaya -- Pharmacology of TRPV Channels / Ulrich Wissenbach -- Part III. Pathologies of Ligand-Gated Calcium Channels -- IP 3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington's and Alzheimer's Diseases / Masayoshi Tada, Masatoyo Nishizawa and Osamu Onodera -- RyR2 in Cardiac Disorders / Ineke Nederend, Christian van der Werf and Arthur A.M. Wilde -- P2X Receptors and Pain / François Rassendren and Lauriane Ulmann -- P2X7 in Bipolar and Depressive Disorders / Melissa L. Barron, Eryn L. Werry, Iain S. McGregor and Michael Kassiou -- Targeting NMDA Receptors in Epilepsy / Mehdi Ghasemi and Ahmad Reza Dehpour -- Nicotinic AChR in Congenital Myasthenic Syndromes / Francesca Grassi and Sergio Fucile -- CatSper in Male Infertility / Takuya Nishigaki, Ana Laura González-Cota and Gerardo José Orta Salazar
Summary Calcium ions represent Mother Nature's "ion-of-choice" for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed November 11, 2013)
Subject Calcium channels.
Calcium ions.
Calcium in the body.
Calcium Signaling.
Form Electronic book
Author Weiss, Norbert, editor
Koschak, Alexandra, editor
ISBN 9783642402821 (electronic bk.)
3642402828 (electronic bk.)