| Description |
1 online resource (xii, 52 pages) : illustrations (some color) |
| Series |
SpringerBriefs in stem cells, 2192-8118 |
|
SpringerBriefs in stem cells
|
| Contents |
Calcium Handling in hiPSC-Derived Cardiomyocytes -- Myocardial Infarction and Heart Failure -- Embryonic Stem Cells/Pluripotent Stem Cells -- Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocytes as a Source for Cardiac Regeneration -- Spontaneous Cardiac Differentiation -- Mesoderm Enrichment by Wnt-Signaling Growth Factors -- Endoderm-Like Cell (END)-2 Co-culture Method -- Calcium Homeostasis in Cardiomyocytes -- Sarcoplasmic Reticulum (SR) Governs Maturity of Cardiomyocytes -- SR Junctional Proteins Play a Role in Calcium Flux Between Cytosol and SR -- Spatial and Temporal Ca2+ Wavefront Dictated by T-Tubule Structure -- IP3-Mediated Calcium Release Contributes to Whole-Cell Calcium Transients -- Calcium Handling Properties of hES-Derived Cardiomyocytes -- Calcium Handling Properties of hiPSC-Derived Cardiomyocytes -- iPSC-Derived Cardiomyocyte as a Potential Platform for Disease Modeling of the Impaired Calcium Handling-Related Syndrome -- Disease Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) -- Mitochondrial Dysfunction-Related Cardiomyopathy-Impaired SR Ca2+ Reuptake -- Measurement of Cytosolic [Ca2+] by Fluorescence Confocal Microscopy -- Materials -- Calibration of Fluo-3 -- Isolation of hiPSC- and hESC-Derived Cardiomyocytes -- Recording of Cytosolic [Ca2+] -- RT-qPCR of Calcium Handling Proteins |
| Summary |
Annotation Calcium is crucial in governing contractile activities of myofilaments in cardiomyocytes, any defeats in calcium homeostasis of the cells would adversely affect heart pumping action. The characterization of calcium handling properties in human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMCs) is of significant interest and pertinent to the stem cell and cardiac regenerative field because of their potential patient-specific therapeutic use |
| Analysis |
Life sciences |
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Cardiology |
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Cytology |
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Stem cells |
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Cell Biology |
|
calcium |
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celbiologie |
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cellular biology |
|
stamcellen |
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cardiologie |
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cardiomyopathie |
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cardiomyopathy |
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Medicine (General) |
|
Geneeskunde (algemeen) |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Heart cells.
|
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Stem cells.
|
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Calcium -- Physiological effect.
|
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Calcium -- physiology
|
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Induced Pluripotent Stem Cells
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Myocytes, Cardiac
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Stem Cells
|
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MEDICAL -- Surgery -- Transplant.
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Calcium -- Physiological effect
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Heart cells
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Stem cells
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| Form |
Electronic book
|
| Author |
Siu, Chung-Wah
|
| ISBN |
9781461440932 |
|
1461440939 |
|
9781461440925 |
|
1461440920 |
|
