| Description |
1 online resource (xxi, 481 pages) : illustrations (some color) |
| Contents |
Part 1. SOCE -- Fundamental mechanistic concepts -- Introduction / James W. Putney -- The STIM-Orai Pathway / Structural Insights into Ca2+ Sensing by Stromal Interaction Molecules / Peter B. Stathopulos and Mitsuhiko Ikura -- The STIM-Orai Pathway / Orai, the Pore-Forming Subunit of the CRAC Channel / Patrick G. Hogan -- The STIM-Orai Pathway / The Interactions Between STIM1 and Orai / Rainer Schindl, Marc Fahrner, Martin Muik and Christoph Romanin -- STIM-TRP Pathways / The STIM1/Orai/TRPC Channels Multiple Ca2+ Influx Complexes / Jeong Hee Hong, Min Seuk Kim, Kyu Pil Lee, Joseph P. Yuan and Shmuel Muallem -- STIM-TRP Pathways / Function and Regulation of TRPC1: Contribution to Ca2+ Entry Activated by Store Depletion / Indu S. Ambudkar, Kwong Tai Cheng, Hwei Ling Ong and Xibao Liu -- Microdomain Organization and the Role of Second Messengers / Microdomain Organization of SOCE Signaling / Claudia Moreno and Luis Vaca -- Microdomain Organization and the Role of Second Messengers / Store-operated Ca2+ Entry: Endogenous Messengers and Mediators / Victoria M. Bolotina |
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Part 2. SOCE -- Crosstalk between organelle and cellular compartments -- Introduction: Ca2+ Signaling and Gene Regulation: An Introduction / Anant B. Parekh -- New Aspects of the Contribution of ER to SOCE Regulation / The Role of the ER and ER-Plasma Membrane Junctions in the Regulation of SOCE / Hayley Dingsdale, Lee Haynes, Gyorgy Lur and Alexei Tepikin -- New Aspects of the Contribution of ER to SOCE Regulation / The Contribution of SERCA to the Regulation of SOCE / Javier García-Sancho and María Teresa Alonso -- New Aspects of the Contribution of ER to SOCE Regulation / TRPC Proteins as a Link between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores / Alexis Bavencoffe and Michael Xi Zhu -- The Role of Mitochondria in the Activation/Maintenance of SOCE / Store-operated Ca2+ Entry and Mitochondria / András Spät and Gergö Szanda -- The Role of Mitochondria in the Activation/Maintenance of SOCE / Local Regulation of Plasma Membrane Channels by Mitochondria / Nicolas Demaurex and Maud Frieden -- The Role of Mitochondria in the Activation/Maintenance of SOCE / The Contribution of Distinct Mitochondrial Ca2+ Uptake Mechanisms, Mitochondrial Motility and Location to Store-operated Ca2+ Entry / Roland Malli and Wolfgang F. Graier -- Tissue Specificity / The Role of Nanospaces between the Organellar Membranes in Smooth Muscle Ca2+ Signaling / Nicola Fameli, A. Mark Evans and Cornelis van Breemen -- Tissue Specificity / SOCE: Implications for Ca2+ Handling in Endothelial Cells / Lothar A. Blatter |
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Part 3. SOCE -- Molecular and cellular (patho)physiology -- Introduction / Juan A. Rosado -- Immune System / SOCE Mediated by STIM and ORAI Proteins in Immune Function and Disease / Stefan Feske -- Cardiovascular System / STIM1/Orai1-Mediated Store-operated Ca2+ Entry in Cardiovascular Disease / Rajender K. Motiani and Mohamed Trebak -- Cardiovascular System / TRPC/Orai-Containing Channels, Na+/Ca2+ Exchanger and Ca2+ Handling in Hypertension / Vera A. Golovina -- Cardiovascular System / SOCE and TRPC/STIM/Orai Signaling in Cardiac Myocytes / Hiroyuki Watanabe, Takayoshi Ohba and Hiroshi Ito -- Cardiovascular System / SOCE as a Determinant of Cardiac Pacemaker Activity / David G. Allen, Yue-Kun Ju, J. Liu and Mohammad S. Imtiaz -- Cardiovascular System / SOCE and Ca2+ Handling in Platelet Dysfunction / Jose J. Lopez, Gines M. Salido and Juan A. Rosado -- Cardiovascular System / Store-operated Ca2+ Entry in Endothelial Pathophysiology / Klaus Groschner and Michael Poteser -- Nervous System / Pathophysiological Perspective of Neuronal Store-operated Ca2+ Signaling / Sunitha Bollimuntha, Biswaranjan Pani and Brij B. Singh -- Skeletal Muscle / Store-operated Ca2+ Entry and STIM/Orai Signaling in Skeletal Muscle / Jonathan A. Stiber and Paul B. Rosenberg -- Skeletal Muscle / Store-operated Channels and Ca2+ Handling in Muscular Dystrophy / Urs T. Ruegg, George Shapovalov, Karin Jacobson, Julie Reutenauer-Patte and Hesham Ismail, et al. -- Reproductive System / Store-operated Ca2+ Entry in Germ Cells: Role in Egg Activation / Zoltan Machaty, Chunmin Wang and Kiho Lee |
| Summary |
Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology |
| Analysis |
Medicine |
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Human physiology |
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Cardiology |
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Cytology |
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Biomedicine |
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Molecular Medicine |
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Cell Biology |
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Physics of the Cell |
| Bibliography |
Includes bibliographical references and index |
| Subject |
Calcium in the body.
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Cellular control mechanisms.
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Physiology, Pathological.
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Human beings.
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Humans
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Calcium Signaling
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Disease -- genetics
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Homo sapiens (species)
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MEDICAL -- Biochemistry.
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Calcium in the body
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Cellular control mechanisms
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Physiology, Pathological
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| Form |
Electronic book
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| Author |
Groschner, Klaus
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Graier, Wolfgang F
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Romanin, Christoph
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| ISBN |
9783709109625 |
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3709109620 |
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