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E-book

Title Calcium and bone disorders in children and adolescents / volume editors, Jeremy Allgrove, Nick Shaw
Published Basel ; New York : Karger, 2009

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Description 1 online resource (pages .)
Series Endocrine development ; v. 16
Endocrine development ; v. 16.
Contents Cover; Contents; Foreword; Preface; Voyages of Discovery; Abstract; Vitamin D and Rickets; Parathyroid Hormone; Calcitonin; Parathyroid Hormone-Related Peptide; Fibroblast Growth Factor 23; References; Physiology of Calcium, Phosphate and Magnesium; Abstract; Calcium Physiology; Control of Plasma Calcium; Transmembrane Calcium Transport; Magnesium Metabolism; Phosphate Metabolism; The Calcium Cascade; The Calcium Sensing Receptor; The Parathyroid Glands; Parathyroid Hormone; The PTH Receptors; Intracellular Signalling; The Target Organs; Parathyroid Hormone-Related Peptide; Calcitonin
Alkaline PhosphataseVitamin D Metabolism; Conclusions; References; Physiology of Bone; Abstract; Skeletal Development; Osteoblast Differentiation and Function; Bone and Cartilage Matrix Collagens and Their Modifying Enzymes; Osteocytes and Bone Lining Cells; Osteoclasts; Hormones and Mineral Homeostasis; The Nervous System and Bone; Functional Adaptation of Bone to Load Bearing; Healthy Bones for Life: Nutrition and Exercise in Bone Physiology; Conclusions; References; Bone Biopsy: Indications and Methods; Abstract; Bone Biopsy Procedure; Sample Processing; Histomorphometric Parameters
Bone Metabolism in Children and AdolescentsIndications for Bone Biopsy in Paediatrics; Conclusions; Acknowledgements; References; Bone Densitometry: Current Status and Future Perspectives; Abstract; What Is Bone Mineral Density?; Assessment of Bone Density; Measurement Principles; Dual-Energy X-Ray Absorptiometry; Volumetric Bone Density for Age; Bone Mineral Content for Height; Allometric Approach; Regression Models; Mechanostat Functional Model; Diagnostic Potential of Dual-Energy X-Ray Absorptiometry; Quantitative Computed Tomography
Diagnostic Potential of Quantitative Computed TomographyMagnetic Resonance Imaging; Quantitative Ultrasound; Guidelines; References; A Practical Approach to Hypocalcaemia in Children; Abstract; Physiological Response to Hypocalcaemia; Signs and Symptoms of Hypocalcaemia; Investigations; Aetiology of Hypocalcaemia -- Classification; Hypocalcaemia with Low or Undetectable PTH; The 22q Deletion (Di George) Syndrome; Other Forms of Familial Hypoparathyroidism; Acquired Hypoparathyroidism; Hypomagnesaemia; Hypomagnesaemia with Hypomagnesuria; Hypomagnesaemia with Hypermagnesuria
Acquired HypomagnesaemiaHypocalcaemia with Normal Parathyroid Hormone; Antibodies to the Calcium-Sensing Receptor; Hypocalcaemia with a High Parathyroid Hormone; Disorder of Vitamin D Supply or Metabolism; Osteopetrosis; Treatment; Conclusions; References; A Practical Approach to Problems of Hypercalcaemia; Abstract; Steady State Calcium Homeostasis; Pathophysiology of Hypercalcaemia; Clinical Features and Clinical Evaluation of Hypercalcaemia; Investigation of Hypercalcaemia; Specific Conditions Leading to Hypercalcaemia during Childhood
Summary Over recent decades, innovative diagnostic technologies, new therapeutic approaches and steady progress in medical genetics have helped establish the field of bone disease as a stand-alone specialty. Summarizing current knowledge, the physiology of calcium, magnesium and phosphate metabolism, the technique of bone biopsy and uses and pitfalls of bone density scanning are discussed. The main part of this publication describes in detail the disorders associated with hypocalcemia, hypercalcemia, rickets, phosphate metabolism, primary and secondary osteoporosis. The genetic nature of many of these conditions is highlighted and each condition is referred to by the number of its OMIM entry. The final chapter, which distinguishes this book from previous publications on the topic, comprises case reports illustrating some of the problems that are examined in previous chapters. This comprehensive account of disorders related to bone and mineral metabolism makes essential reading for pediatric endocrinologists as well as for clinicians who wish to gain a practical understanding of this important topic
Bibliography Includes bibliographical references and indexes
Notes Print version record
Subject Bone diseases in children -- Case studies
Calcium metabolism disorders in children -- Case studies
Children.
Human beings.
Adolescent
Child
Humans
Calcium Metabolism Disorders -- physiopathology
Bone Diseases -- physiopathology
children (people by age group)
Homo sapiens (species)
Children
Bone diseases in children
Calcium metabolism disorders in children
Genre/Form Case studies
Form Electronic book
Author Allgrove, Jeremy
Shaw, Nick
S. Karger (Firm)
LC no. 2009018333
ISBN 9783805591621
3805591624
1283153491
9781283153492
3805591616
9783805591614