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Book Cover

Title Calcium signalling and disease : molecular pathology of calcium / edited by Ernesto Carafoli and Marisa Brini
Published New York : Springer, 2007
Online access available from:
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Description 1 online resource (xii, 566 pages, 26 unnumbered pages) : illustrations (some color)
Series Subcellular biochemistry ; v. 45
Sub-cellular biochemistry ; v. 45
Contents Annexinopathies / M.J. Hayes [and others] -- Calpains and human disease / I. Bertipaglia and E. Carafoli -- Gelsolin and diseases / L. Spinardi and W. Witke -- Guanylate cyclase-activating proteins and retina disease / W. Baehr and K. Palczewski -- Pathologies involving the S100 proteins and rage / C.W. Heizmann [and others] -- The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics / E.M. Brown -- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease / J. Colomer and A.R. Means -- Calcium channelopathies: Voltage-gated calcium channels / P.J. Adams and T.P. Snutch -- TRP channels in disease / S.E. Jordt and B.E. Ehrlich -- Diseases associated with altered ryanodine receptor activity / W.J. Durham [and others] -- Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease / I. Bezprozvanny -- SERCA pumps and human diseases / A. Hovnanian -- The plasma membrane calcium ATPase and disease / B.L. Tempel and D.J. Shilling -- Diseases involving the Golgi calcium pump / J. Vanoevelen [and others] -- Calcium signalling and cancer cell growth / T. Capiod [and others] -- Calcium misregulation and the pathogenesis of muscular dystrophy / F.W. Hopf [and others] -- Calcium and cell death / A. Verkhratsky -- Calcium and cell death: The mitochondrial connection / P. Bernardi and A. Rasola -- Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models / K.N. Green [and others] -- Calcium and cardiomyopathies / E.G. Kranias and D.M. Bers -- Calcium signalling and calcium transport in bone disease / H.C. Blair [and others]
Summary This topic is a new entry in the area of cellular calcium signaling: yet, it now spans the entire area, with discoveries that cover both genetic and acquired pathologies, even offering glimpses in the direction of therapy. Cellular calcium homeostasis, and thus calcium signalling, is mainly regulated by membrane intrinsic proteins and calcium sensor proteins. Both classes may be involved in pathological processes that affect both human and animals, ranging from common and important diseases (e.g. migraine, diabetes, epilepsia, manic depression, infertility, various types of cancer, Alzheimer's disease, muscular dystrophy) to rare genetic conditions (e.g., a number of genetic heart conditions, autoimmune retinopathies, night blindness, hereditary amyloid polyneuropathy, malignant hyperthermia, cerebellar ataxia, atherothrombotic disease). Clearly, the topic has now become not only very large, but also very stimulating. Its extensive critical coverage is likely to eventually stimulate fruitful interdisciplinary discussions
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Calcium -- Pathophysiology.
Calcium -- Physiological effect.
Calcium Signaling.
Calcium Channels.
Calcium Metabolism Disorders.
Calcium -- physiology.
Form Electronic book
Author Brini, Marisa.
Carafoli, Ernesto.
ISBN 1402061900