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Book Cover
Author Kaestner, Lars

Title Calcium signalling : approaches and findings in the heart and blood / Lars Kaestner
Published Berlin : Springer Medizin, [2013]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource (250 pages) : illustrations
Contents Summary -- Introduction -- Direct evidence -- the digital approach -- Fluorescence-based visualisation -- Aequorin-based measurements -- Measurement of calcium transport across membranes -- Molecular biology based approaches -- Manipulation of calcium -- Calcium-induced function -- Calcium signalling in cardiac myocytes -- Calcium signalling in red blood cells -- Perspective -- Calcium signalling methodology -- Non-linear and ultra high-speed imaging for explorations of the murine and human heart -- A system for optical high resolution screening of electrical excitable cells -- Concepts for optical high content screens of excitable primary isolated cells -- A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes -- Calcium imaging of individual erythrocytes: problems and approaches -- Calcium signalling in cardiac myocytes -- Reduced cardiac l-type Ca²+ current in Cavß ₂ -/- embryos impairs cardiac development and contraction with secondary defects in vascular maturation -- Overexpression of junctin causes adaptive changes in cardiac myocyte Ca²+ signaling -- Remodelling of Ca²+ handling organelles in adult rat ventricular myocytes during longterm culture -- Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin d supplement -- Calcium signalling in red blood cells -- The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation -- Ion channels in the human red blood cell membrane: their further investigation and physiological relevance -- Prostaglandin e₂ activates channelmediated calcium entry in human erythrocytes: an indication for a blood clot formation supporting process -- Functional nmda receptors in rat erythrocytes -- Stimulation of human red blood cells leads to Ca²+-mediated intercellular adhesion -- Lysophospatidic acid induced red blood cell aggregation in vitro -- Regulation of phosphatidylserine exposure in red blood cells -- Cation channels in erythrocytes -- historical and future perspective
Summary The book combines general concepts and methods to investigate calcium signalling in cells ranging from molecular biology approaches to manipulation of calcium in living cells. The focus within these methods in on the broad range of fluorescence imaging technology, in particular on optical sectioning techniques and fast image acquisition. In addition to these general guidelines there are application examples in a context beyond calcium signalling in two major fields: investigations of isolated cardiac myocytes and red blood cell related research. While the cellular cardiology section provides snapshots of certain calcium signalling aspects, the red blood cell part presents an overview from the functional identification of calcium-channels to a concept of physiological and pathophysiological relevance
Analysis Medicine
Human physiology
Cell Biology
Bibliography Includes bibliographical references and index
Notes Online resource; title from digital title page (SpringerLink, viewed on November 11, 2014)
Subject Calcium -- Physiological effect.
Intracellular calcium.
Cellular signal transduction.
Blood -- metabolism.
Heart -- physiology.
Calcium Signaling.
Calcium -- physiology.
Signal Transduction.
Form Electronic book
ISBN 9783642346170 (electronic bk.)
3642346170 (electronic bk.)
9781283935401 (MyiLibrary)
1283935406 (MyiLibrary)
(hbk. ;) (alk. paper)
(hbk. ;) (alk. paper)