| Description |
1 online resource |
| Contents |
Antiplatelet Therapy in Cardiovascular Disease; Copyright; Contents; List of Contributors; Foreword; Preface; Section I Platelet Biology and Pathophysiology; 1 Platelet Pathophysiology and its Role in Thrombosis; Role of platelets during initiation of atherosclerosis and plaque formation; Role of platelets in thrombosis; References; 2 Platelet Receptors and Drug Targets: COX-1; Structure, expression, and catalytic activity of platelet COX-1; Functional role of platelet COX -1; Genetic polymorphisms of COX-1 and COX-2 expression in platelets |
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Platelet COX-1 as a target for antithrombotic therapyInteraction between aspirin and naNSAIDs at the level of platelet COX-1; In vitro and in vivo evidence for aspirin/naNSAID interaction; Concluding remarks; References; 3 Platelet Receptors and Drug Targets: P2Y12; P2 receptors; Roles of adenine nucleotides in platelet function; P2Y12; Conclusions; References; 4 Platelet Receptors and Drug Targets: GP IIb/IIIa; Introduction; Biology of the receptor; Glycoprotein IIb/IIIa receptor in platelet physiology; Platelet aggregation phase; "Inside-out" and "outside-in" GPIIb/IIIa signaling phenomenon |
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Glycoprotein IIb/IIIa receptor and thrombus formationGlycoprotein IIb/IIIa receptor antagonists; Intravenous versus oral preparations: clinical aspects; Acknowledgment; References; 5 Platelet Receptors and Drug Targets: PAR1, Collagen, vWF, Thromboxane, and Other Novel Targets; Introduction; Protease-activated receptor 1 (PAR1); References; 6 Role of Inflammation and Hypercoagulability in Thrombosis; References; Section II Platelet Function Tests; 7 Light Transmission Aggregometry; Technique; References; 8 Vasodilator-Stimulated Phosphoprotein (VASP) Assay; Introduction; The VASP index assay |
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VASP index and clinical eventsAlteration of antiplatelet therapy based on the VASP index; VASP index and new oral antiplatelet agents; Conclusions; References; 9 VerifyNow P2Y12 and Plateletworks Assays; Introduction; Verifynow P2Y12; Plateletworks; Validity of the test in measuring antiplatelet effect and its association with clinical outcomes; Conclusion; References; 10 Multiplate Analyzer; Historical background; Principles of the Multiplate® analyzer; Advantages; Disadvantages; Clinical studies in cardiovascular medicine; Studies in cardiovascular surgery |
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Consensus definitions and cutoff values concerning platelet reactivitySummary; Acknowledgment; References; 11 Shear Stress-Based Platelet Function Tests; PFA-100; IMPACT-R; References; 12 Thrombelastography and Other Novel Techniques; Novel techniques; T2 magnetic resonance (T2MR); Shear-induced platelet aggregation assays; References; Section III Antiplatelet pharmacology; 13 Aspirin; Mode of antiplatelet action; Time dependency of inhibition of platelet function by aspirin; Dose-dependent inhibition of platelet function by aspirin; Negative interactions with other drugs |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record and CIP data provided by publisher |
| Subject |
Cardiovascular system -- Diseases -- Chemotherapy
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Anticoagulants (Medicine)
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Cardiovascular Agents -- therapeutic use
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Platelet Aggregation Inhibitors -- therapeutic use
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Anticoagulants
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Cardiovascular Diseases -- blood
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Cardiovascular Diseases -- drug therapy
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Platelet Function Tests
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Anticoagulants (Medicine)
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Cardiovascular system -- Diseases -- Chemotherapy
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| Form |
Electronic book
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| Author |
Waksman, Ron, editor
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Gurbel, Paul A., editor
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Gaglia, Michael A., Jr, editor.
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| LC no. |
2013051093 |
| ISBN |
9781118494028 |
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1118494024 |
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9781118494011 |
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1118494016 |
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9781118493984 |
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1118493982 |
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1118275756 |
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9781118275757 |
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