| Description |
1 online resource : illustrations |
| Contents |
Cover -- Title page -- Copyright page -- Preface -- Acknowledgment -- Contents -- List of Figures -- List of Tables -- List of Foundations -- Part 1 Introduction -- 1 Evolutionary Cell Biology -- The Dominance of Unicellular Life -- What is Evolutionary Cell Biology? -- The Completeness of Evolutionary Theory -- Evolution Via Nonadaptive Pathways -- The Grand Challenges -- The origin of life -- The roots of organismal complexity -- Molecular stochasticity -- Molecular complexes -- Cellular networks -- Cellular surveillance systems -- Growth regulation -- Biological scaling laws |
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2 The Origin of Cells -- The Earliest Stages -- The alkaline hydrothermal-vent hypothesis -- The terrestrial geothermal-field hypothesis -- An Early RNA World? -- Membranes and the Emergence of Individuality -- Genomic Constraints on the Establishment of Life -- 3 The Major Lines of Descent -- The Primary Domains of Life -- Times of Origin -- The Emergence of Eukaryotes -- The stem eukaryote -- The eukaryotic radiation -- A eukaryotic Big Bang? -- Part 2 The Genetic Mechanisms of Evolution -- 4 The Population-Genetic Environment -- Demystifying Random Genetic Drift |
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The Genetic Effective Sizes of Populations -- Probability of Fixation of a Mutant Allele -- Evolution of the Mutation Rate -- High mutability of mutation rates -- Error-prone polymerases -- Optimizing the mutation rate -- The non-random nature of mutation -- Recombination -- Evolution of the recombination rate -- 5 Evolution as a Population-Genetic Process -- The Perils of the Adaptive Paradigm -- The Fitness Effects of New Mutations -- The Classical Model of Sequential Fixation -- Vaulting Barriers to More Complex Adaptations -- Sequential fixation versus stochastic tunnelling |
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Two-locus transitions -- More complex scenarios -- Effects of recombination -- The Phylogenetic Dispersion of Mean Phenotypes -- Two-state traits -- Multistate-traits and the drift-barrier hypothesis -- 6 Evolution of Cellular Complexity -- Illusions of Grandeur -- Constructive Neutral Evolution -- Ribosomes -- Evolution by Gene Duplication -- The masking effect -- Neofunctionalization -- Subfunctionalization -- Adaptive-conflict resolution -- The Case for Subfunctionalization -- The Emergence of Modular Gene Subfunctions -- The Passive Origin of Species via Gene Duplication |
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Part 3 Basic Cellular Features -- 7 The Cellular Environment -- The Molecular Composition of Cells -- Water -- Elemental composition -- Biomolecules -- Numbers of Biomolecules per Cell -- Passive Transport of Particles through the Cytoplasm -- Intermolecular Encounter Rates -- Temperature-Dependence of Biological Processes -- Energy, Carbon Skeletons, and Cell Yield -- 8 Evolutionary Scaling Relationships in Cell Biology -- Describing Allometric Relationships -- Scaling Laws in Cellular Bioenergetics -- Metabolic rate -- Lifetime energy requirements of a cell |
| Summary |
Establishes the foundations of the emerging field of evolutionary cell biology, providing a deep and broad coverage of the literature, with many ideas synthesised and presented for the first time |
| Notes |
Also issued in print: 2024 |
| Bibliography |
Includes bibliographical references and index |
| Audience |
Specialized |
| Notes |
Description based on online resource and publisher information; title from PDF title page (viewed on January 30, 2024) |
| Subject |
Cytology.
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Cells -- Evolution.
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Cell physiology
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Evolution (Biology)
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| Genre/Form |
Electronic books
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| Form |
Electronic book
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| ISBN |
9780191939662 |
|
0191939668 |
|
9780192663030 |
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0192663038 |
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