| Description |
1 online resource (532 pages) |
| Series |
Springer Series in Translational Stroke Research |
|
Springer series in translational stroke research.
|
| Contents |
Contents -- Part I: Stem Cells -- Chapter 1: Stroke: Cytoprotection, Repair and Regeneration#x80;#x94;The Continuum of Patient Care -- 1 Introduction -- 2 Cellular Measures of Metabolism and Penumbra -- 2.1 Nicotinamide Adenosine Dinucleotide (NADH) Penumbra Mapping: A New Technique -- 3 Cytoprotection: What a Time for Intervention? -- 4 The Stroke Cascade and Current Intervention Attempts Toward Efficacy -- 5 Critical Targets for Rapid Intervention -- 5.1 Energy Depletion and Cell Death -- 5.2 Excitotoxicity -- 5.3 Oxidative Stress -- 5.4 Immunotherapy |
|
6 Regeneration, Repair and Repopulation6.1 What Happens to the Stroke Victim When Penumbra No Longer Exists as a Target for Intervention? -- 7 Conclusion -- References -- Chapter 2: Interdisciplinary Advances Towards Understanding and Enhancing the Therapeutic Potential of Stem Cell-Based Therapies for Ischaemic Stroke -- 1 Introduction -- 2 Therapeutic Approaches and Evaluation of the Post-stroke Microenvironment -- 2.1 The Neuroprotective Effect of Stem Cell-Based Therapies -- 2.1.1 The Complexity of the Ischaemic Cascade |
|
2.1.2 Stem Cell-Mediated Neuroprotection2.2 Regeneration of Endogenous Tissue by Stem Cells After Ischaemic Stroke -- 2.2.1 Vascular Remodelling After Stroke -- 2.2.2 Endogenous Regeneration After Stroke -- 2.2.3 ECM and Scar Tissue Remodelling -- 2.3 Immunomodulatory Properties of Candidate Stem Cell-Based Therapies for Ischaemic Stroke -- 2.3.1 Introduction to Stroke Immunology -- 2.3.2 Mechanisms of Stem Cell-Mediated Immunomodulation -- 3 Noninvasive Monitoring of Stem Cells in the Stroke Microenvironment -- 4 Conclusion -- References |
|
Chapter 3: Stem Cell Transplants in the Aged Stroke Brain: Microenvironment Factors1 Introduction -- 2 Age Is the Principal Risk Factor for Stroke -- 3 Stroke Commorbidities -- 4 Stroke Models Using Aged Animals Are Clinically More Relevant -- 4.1 Spontaneous Stroke Recovery in Aged Patients and Animals -- 5 Stroke Therapy in Aged Subjects Using G-CSF -- 6 Cell Therapy of Stroke Using a Combination Therapy -- 7 Co-administration of G-CSF and BM-MSC in the Microenvironment of the Post-stroke Aged Rats |
|
8 Functional Neurological Recovery and Tissue Repair After Neural Tissue Transplantation9 Stem Cell Therapy in Subcortical Stroke. Role of Endogenous Neurogenesis and Aging -- 10 Mesenchymal Cells Can Be Used as Drug Carriers for Stroke Therapy -- 11 Angiogenesis After Stroke in the Aged Brains -- 12 Conclusions -- References -- Chapter 4: Modulating Endogenous Adult Neural Stem Cells to Improve Regeneration in Stroke Brain -- 1 Introduction -- 2 NSCs Responses in Adult Brain Following Stroke -- 2.1 Radial Glial Cells (Type B Cells) in SVZ |
| Summary |
This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to understand the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke |
| Notes |
""2.2 Radial Glia-Like Cells (Type-1 Cells) in SGZ"" |
| Bibliography |
Includes bibliographical references |
| Notes |
Print version record |
| Subject |
Regenerative medicine.
|
|
Stem cells -- Therapeutic use
|
|
Stem cells.
|
|
Cellular therapy.
|
|
Stroke -- therapy
|
|
Regenerative Medicine
|
|
Stem Cells
|
|
Cell- and Tissue-Based Therapy
|
|
HEALTH & FITNESS -- Holism.
|
|
HEALTH & FITNESS -- Reference.
|
|
MEDICAL -- Alternative Medicine.
|
|
MEDICAL -- Atlases.
|
|
MEDICAL -- Essays.
|
|
MEDICAL -- Family & General Practice.
|
|
MEDICAL -- Holistic Medicine.
|
|
MEDICAL -- Osteopathy.
|
|
Stem cells
|
|
Cellular therapy
|
|
Regenerative medicine
|
| Form |
Electronic book
|
| Author |
Lapchak, Paul A.
|
|
Zhang, J. H. (John H.)
|
| ISBN |
9783319666792 |
|
3319666797 |
|
