Title Gene and cell therapy : therapeutic mechanisms and strategies / edited by Nancy Smyth Templeton

Edition 2nd ed., rev. and expanded Published New York : Marcel Dekker, ©2004

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Description 1 online resource (xviii, 875, [32] pages) : illustrations (some color) Series BIOSCIENCEnetBASE Contents Foreword : The Past Recalls the Future / Phillip David Noguchi -- Part I. Delivery Systems and Therapeutic Strategies -- 1. Retroviral Vectors for Gene Therapy / Paula M. Cannon and W. French Anderson -- 2. Adenovirus Vectors for Gene Therapy / Neil R. Hackett and Ronald G. Crystal -- 3. Modified Adenoviruses for Gene Therapy / Akseli Hemminki, Joel N. Glasgow, and David T. Curiel -- 4. Helper-dependent Adenoviral Vectors for Gene Therapy / Philip Ng and Frank L. Graham -- 5. Adeno-associated Virus and AAV Vectors for Gene Delivery / Barrie J. Carter, Haim Burstein, and Richard W. Peluso -- 6. Engineering Herpes Simplex Viral Vectors for Therapeutic Gene Transfer / D. Wolfe [and others] -- 7. Lentiviral Vectors / Douglas Jolly -- 8. Ex Vivo Gene Therapy Using Myoblasts and Regulatable Retroviral Vectors / Clare R. Ozawa, Matthew L. Springer, and Helen M. Blau -- 9. Vaccinia Viral Vectors / J. Andrea McCart and David L. Bartlett -- 10. Baculovirus-mediated Gene Transfer : An Evolving New Concept / Kari J. Airenne [and others] -- 11. Bacteria as Vectors for Gene Therapy of Cancer / Annette Paschen, Dirk Schadendorf, and Siegfried Weiss -- 12. Polyfunctional Vectors for Gene Delivery / Barbara Demeneix and Jean-Paul Behr -- 13. Receptor-Targeted Polyplexes / Kurosh Ameri and Ernst Wagner -- 14. Electrokinetic Enhancement of Plasmid Delivery In Vivo / Ruxandra Draghia-Akli and Louis C. Smith -- 15. Gene Gun Technologies : Applications for Gene Therapy and Genetic Immunization / Michael A. Barry, Rana A.K. Singh, and Helen A. Andersson -- 16. Optimization of Nonviral Gene Therapeutics / Nancy Smyth Templeton -- 17. Molecular Interactions in Lipids, DNA, and DNA-Lipid Complexes / Rudolf Podgornik [and others] -- Part II. Other Therapeutic Strategies -- 18. Gene Therapy Applications of Ribozymes / Bruce A. Sullenger, Lynn Milich, and J.P. Jones III -- 19. Antisense Oligonucleotide-based Therapeutics / C. Frank Bennet [and others] -- 20. Suicide Gene Therapy / Bert W. O'Malley, Jr. -- 21. Selectable Markers for Gene Therapy / Michael M. Gottesman [and others] -- Part III. Gene Expression and Detection -- 22. Ligand-dependent Transcription Switches and Their Potential for Gene Therapy / Carlo Toniatti [and others] -- 23. Monitoring Gene Therapy in Living Subjects with Molecular Imaging Technologies / S. Biswal and S.S. Gambhir -- Part IV. Disease Targets and Therapeutic Strategies -- 24. Gene Transfer into Hematopoietic Stem Cells / David M. Bodine -- 25. Gene Therapy for Hematopoietic Disorders / Mitchell E. Horwitz and Harry L. Malech -- 26. Gene Therapy for Cardiovascular Disease and Vascular Grafts / Abeel A. Mangi and Victor J. Dzau -- 27. Gene Therapy for Cancer / Karsten Brand -- 28. Overcoming Barriers to Efficient Airway Epithelial Gene Transfer / Larry G. Johnson -- 29. Gene Therapy for Neurological Diseases / William J. Bowers and Howard J. Federoff -- 30. Principles of Gene Therapy for Inborn Errors of Metabolism / Jon A. Wolff and Cary O. Harding -- 31. Gene Therapy and HIV-1 Infection / Muhammad Mukhtar, Ralph Dornburg, and Roger J. Pomerantz -- 32. Cutaneous Gene Therapy for Skin and Systemic Disorders / William F. Buitrago and Dennis R. Roop -- 33. Gene Therapy for Childhood Onset Blindness / Jean Bennett -- 34. DNA Vaccines / J. Joseph Kim, Andrew Y. Choo, and David B. Weiner -- Part V. Gene Therapy Clinical Trials and Regulatory Issues -- 35. Cardiovascular Gene Therapy / Pinak B. Shah, Kapildeo Lotun, and Douglas W. Losordo -- 36. Selectively Replicating Adenoviruses : Clinical Experience with Onyx015 and Future Directions / Leonard E. Post -- 37. Gene Therapy for the Treatment of Cancer : From Laboratory to Bedside / Raphael F. Rousseau [and others] -- 38. Gene Therapy Clinical Trials for Cancer : Replacement of Tumor Suppressor Gene p53 / Jack A. Roth [and others] -- 39. Ex Vivo Gene Therapy for Alzheimer's Disease / Peter Nakaji and Hoi Sang U -- 40. Prospects for Clinical Application of Synthetic Gene Delivery Vectors / Nelson S. Yew and Seng H. Cheng -- 41. Regulatory Aspects of Gene Therapy / Stephanie L. Simek and Maritza C. McIntyre -- Part VI. Other Cell-based Therapies and Trials -- 42. Immunoisolated Cells as Gene Therapy for CNS Diseases / Dwaine F. Emerich -- 43. Hematopoietic Progenitor Cells / Shannon L. McKinney-Freeman, Steven B. Bradfute, and Margaret A. Goodell -- 44. Gene Marking Studies of Hematopoietic Cells / Catherine M. Bollard, Malcolm K. Brenner, and Helen E. Heslop -- 45. Gene-based Vaccination Against Malignant Melanoma / Dirk Schadendorf Summary This book offers current data on delivery systems and therapeutic strategies, gene expression and detection, and disease targets and therapeutic strategies. It presents results and prospects in gene therapy clinical trials, other cell-based therapies and trials, and regulatory issues Notes Previous edition published as Gene therapy, 2000 Bibliography Includes bibliographical references and index Notes Print version record Subject Gene therapy. Cellular therapy. Genetic Therapy -- methods Cell Transplantation -- methods Genetic Therapy Cell- and Tissue-Based Therapy HEALTH & FITNESS -- Diseases -- Genetic. MEDICAL -- Genetics. Cellular therapy Gene therapy Form Electronic book Author Templeton, Nancy Smyth, 1952- Templeton, Nancy Smyth, 1952- Gene therapy ISBN 0824758609 9780824758608 9780203025796 0203025792

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