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Title The centrosome : cell and molecular mechanisms of functions and dysfunctions in disease / Heide Schatten, editor
Published New York : Humana Press, [2012]
Online access available from:
Springer eBooks    View Resource Record  


Description 1 online resource : illustrations (some color)
Contents Part 1. Centrosomes in Reproduction -- Centriole Duplication and Inheritance in Drosophila melanogaster / Tomer Avidor-Reiss, Jayachandran Gopalakrishnan, Stephanie Blachon and Andrey Polyanovsky -- Sperm Centrioles and Their Dual Role in Flagellogenesis and Cell Cycle of the Zygote: Structure, Function, and Pathology / Hector E. Chemes -- Centrosomal Functions and Dysfunctions in Cat Spermatozoa / Pierre Comizzoli and David E. Wildt -- Nuclear-Centrosome Relationships During Fertilization, Cell Division, Embryo Development, and in Somatic Cell Nuclear Transfer Embryos / Heide Schatten and Qing-Yuan Sun -- Human Centrosomal Dynamics During Gametogenesis, Fertilization, and Embryogenesis and Its Impact on Fertility: Ultrastructural Analysis / A. Henry Sathananthan -- Asymmetric Centrosome Behavior in Stem Cell Divisions / Therese M. Roth, Yukiko M. Yamashita and Jun Cheng
Part 2. Cell and Molecular Biology of Centrosomes -- Functional Associations Between the Golgi Apparatus and the Centrosome in Mammalian Cells / Breanne Karanikolas and Christine Sütterlin -- Many Pathways to Destruction: The Role of the Centrosome in, and Its Control by Regulated Proteolysis / Harold A. Fisk -- Regulation of the Centrosome Cycle by Protein Degradation / Suzanna L. Prosser and Andrew M. Fry -- Molecular Links Between Centrosome Duplication and Other Cell Cycle-Associated Events / Kenji Fukasawa -- Regulation of Centrosomes by Cyclin-Dependent Kinases / Rose Boutros
Part 3. Centrosome Abnormalities in Cancer -- Disruption of Centrosome Duplication Control and Induction of Mitotic Instability by the High-Risk Human Papillomavirus Oncoproteins E6 and E7 / Nina Korzeniewski and Stefan Duensing -- Centrosomes, DNA Damage and Aneuploidy / Chiara Saladino, Emer Bourke and Ciaran G. Morrison -- Centrosome Regulation and Breast Cancer / Zeina Kais and Jeffrey D. Parvin -- The Role of Centrosomes in Multiple Myeloma / Benedict Yan and Wee-Joo Chng -- Centrosomal Amplification and Related Abnormalities Induced by Nucleoside Analogs / Ofelia A. Olivero -- Mechanisms and Consequences of Centrosome Clustering in Cancer Cells / Alwin Krämer, Simon Anderhub and Bettina Maier
Part 4. Centrosomes in Other Systems -- Re-evaluation of the Neuronal Centrosome as a Generator of Microtubules for Axons and Dendrites / Peter W. Baas and Aditi Falnikar -- Centrosomes and Cell Division in Apicomplexa / Leandro Lemgruber, Marek Cyrklaff and Freddy Frischknecht -- The Centrosome Life Story in Xenopuslaevis / Jacek Z. Kubiak and Claude Prigent -- Role of the MTOC in T Cell Effector Functions / Martin Poenie, Laura Christian, Sarah Tan and Yuri Sykulev -- Thoughts on Progress in the Centrosome Field / Jeffrey L. Salisbury
Summary "The Centrosome: Cell and Molecular Mechanisms of Functions and Dysfunctions in Disease" includes chapters on classic and modern aspects of centrosome research to cover topics of current interest that have not been covered in depth in most books on the market so far. It extends on previous topics and includes new exciting aspects of centrosome research focused on primary cilia and their dysfunctions that are implicated in numerous diseases
Analysis Life sciences
Cell cycle
Cell Biology
Cell Cycle Analysis
Cell Physiology
Bibliography Includes bibliographical references and index
Notes English
Subject Centrosomes.
Biological Science Disciplines.
Microtubule-Organizing Center.
Health Occupations.
Natural Science Disciplines.
Cytoplasmic Structures.
Disciplines and Occupations
Intracellular Space.
Cellular Structures.
Form Electronic book
Author Schatten, Heide.
LC no. 2012942022
ISBN 9781627030359 (electronic bk.)
1627030352 (electronic bk.)