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Title Centrosomes in development and disease / edited by Erich A. Nigg
Published Weinheim : Wiley-VCH, [2004]
Online access available from:
Wiley Online Books    View Resource Record  


Description 1 online resource (xxi, 431 pages) : illustrations (some color)
Contents Centrosomes in a developing organism: lessons from drosophila -- Centrosome inheritance during human fertilization and "therapeutic" cloning: reproductive and developmental diseases and disorders caused by centrosome dysfunction -- Microtubule organizing centers in polarized epithelial cells -- Centrosome anomalies in cancer: from early observations to animal models -- Radiation therapy and centrosome anomalies in pancreatic cancer -- Human papillomavirus infection and centrosome anomalies in cervical cancer -- Manipulation of centrosomes and the microtubule cytoskeleton during infection by intracellular pathogens -- Basal bodies and microtubule organization in pathogenic protozoa
Early studies on centrioles and centrosomes -- Tubulin superfamily -- Microtubule nucleation -- The budding yeast spindle pole body: a centrosome analog -- Dissection of basal body and centriole function in the unicellular green alga chlamydomonas reinhardtii -- The centrosome in evolution -- A proteomic approach to the inventory of the human centrosome -- The role of the centrosome in cell cycle progression -- Centrosome duplication and its regulation in the higher animal cell -- A synergy of technologies: using green fluorescent protein tagging and laser microsurgery to study centrosome function and duplication in vertebrates -- Centrosome regulation in response to environmental and genotoxic stress -- The C. elegans centrosome during early embryonic development
Summary Discovered over a century ago, the centrosome is the major microtubule organizing center of the animal cell. It is a tiny organelle of surprising structural complexity. Over the last few years our understanding of the structure and composition of centrosomes has greatly advanced, and the demonstration of frequent centrosome anomalies in most common human tumors has sparked additional interest in the role of this organelle in a broader scientific community. The centrosome controls the number and distribution of microtubules--a major element of the cell cytoskeleton--and hence influences many impo
Analysis Molecular Biology and Genetics
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Centrosome -- physiology.
Cell Division -- physiology.
Form Electronic book
Author Nigg, Erich A.
John Wiley & Sons.
ISBN 3527309802 (print edition)
3527603808 (electronic bk.)
3527604340 (electronic bk.)
9783527309801 (print edition)
9783527603800 (electronic bk.)
9783527604340 (electronic bk.)