| Description |
1 online resource |
| Series |
Contemporary clinical neuroscience |
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Contemporary clinical neuroscience.
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| Contents |
Intro -- Preface -- The List of Referees -- Contents -- Part I: Basic Science of Cerebellum and Ataxias -- Functional Anatomy of the Cerebellum -- 1 Introduction -- 2 Macroscopic Anatomy of the Cerebellum -- 2.1 Outer Shape and Orientation -- 2.2 The White Matter of the Cerebellum -- 2.3 Cerebellar Nuclei -- 2.4 Cerebellar Lobules in the Vermis -- 2.5 Lobules in the Hemisphere -- 2.6 Unfolded Schemes of the Cerebellar Cortex -- 3 Neuronal Components and Circuitry of the Cerebellum -- 3.1 Purkinje Cells and Climbing Fibers -- 3.2 Molecular Layer Interneurons |
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3.3 Granule Cells, Parallel Fibers, and Mossy Fibers -- 3.4 Golgi Cells and Other Inhibitory Cells in the Granular Layer -- 3.5 Glial Cells in the Cerebellar Cortex -- 3.6 Neurons in the Cerebellar Nuclei -- 4 Afferent Axonal Projections of the Cerebellum -- 4.1 Climbing Fibers Originating from the Inferior Olive -- 4.2 Mossy Fiber Axons -- 4.3 Distribution Pattern of Major Mossy Fiber Axons in the Cerebellar Cortex -- 4.4 Other Afferent Projections to the Cerebellar Cortex -- 4.5 Afferents of the Cerebellar Nuclei -- 5 Compartments or Modules of the Cerebellum |
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5.1 Cerebellar Modules Determined by Projections of Climbing Fibers and Purkinje Cell Axons -- 5.2 Longitudinal Stripes of Molecular Expression in the Cerebellar Cortex -- 5.3 Compartmentalization of the Cerebellar Nuclei -- 6 Output Projections of the Cerebellum -- 6.1 Somatomotor System -- 6.2 Oculomotor System -- 6.3 Various Non-Motor Output Pathways -- 6.4 Inhibitory Output Projection from the Cerebellar Nuclei -- 7 Functional Localization in the Cerebellum -- 7.1 Functional Localization of Vermal Areas -- 7.1.1 Lobules I-VIa and VIII -- 7.1.2 Lobules VIb-c and VII -- 7.1.3 Lobule IXa-b |
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7.1.4 Lobules IXc and X -- 7.2 Functional Localization of Paravermal and Hemispheric Areas -- 7.2.1 Rostral and Caudal Lobules -- 7.2.2 Medial Paravermal Area of Lobules VI and VII (Lateral A Module) -- 7.2.3 Ansiform Area (Crus I in Rodents, Crus I + II in Primates) -- 7.2.4 Paraflocculus -- 7.2.5 Flocculus -- 8 Concluding Remarks -- References -- Cerebellar Physiology -- 1 Introduction -- 2 Basic Cerebellar Structure -- 2.1 Gross Cerebellar Structure -- 2.2 Cerebellar Inputs -- 2.2.1 Basic Anatomy of Climbing Fiber Projections and Olivo-Cortico-Nuclear Circuits |
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2.2.2 Basic Anatomy of Mossy Fiber Projections -- 2.2.3 Neuromodulatory Inputs -- 2.3 Non-uniformity in Cerebellar Anatomy -- 3 Cellular Physiology -- 3.1 Cortical Circuits -- 3.1.1 Inputs to the Granule Cell Layer -- 3.1.2 Parallel Fiber Inputs to the Molecular Layer -- 3.1.3 Purkinje Cell Simple Spikes and Complex Spikes -- 3.1.4 Purkinje Cell Targets Within the Cerebellar Cortex -- 3.2 Purkinje Cell Control of Cerebellar Nuclei -- 3.3 Zebrin Stripes -- 3.4 Synaptic Plasticity -- 3.4.1 Parallel Fiber-Purkinje Cell Synaptic Plasticity -- 3.4.2 Zebrin II and Synaptic Plasticity |
| Summary |
Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field |
| Analysis |
Internal Medicine |
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Medical |
| Notes |
Includes index |
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Online resource; title from PDF title page (SpringerLink, viewed June 13, 2023) |
| Subject |
Cerebellar ataxia.
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Cerebellar Ataxia
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Cerebellar ataxia
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| Form |
Electronic book
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| Author |
Soong, Bing-wen
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Manto, Mario.
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Brice, Alexis.
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Pulst, Stefan-M.
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| ISBN |
9783031243455 |
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3031243455 |
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