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Title Development of the cerebellum from molecular aspects to diseases / Hassan Marzban, editor
Published Cham, Switzerland : Springer, 2017
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Description 1 online resource : illustrations
Series Contemporary clinical neuroscience
Contemporary clinical neuroscience.
Contents Preface; Contents; The Development of the Cerebellum: From the Beginnings; The Origin of the Cerebellum; Histogenesis; Development of the Cerebellar Nuclei; Development of Longitudinal Purkinje Cell Zones; Development of Connections; Development of the Folial Pattern; References; The Embryology and Anatomy of the Cerebellum; Introduction; Embryology of the Cerebellum; Anatomy and Histology of the Human Cerebellum; Functional Divisions of the Cerebellum; Cerebellar Cortex; Cerebellar Nuclei (CN); Cerebellar Peduncles; Cerebellar Function; Blood Supply of the Cerebellum
Origin of Glutamatergic Neurons Origin of GABAergic Projection Neurons; Other GABAergic Neurons; Nucleogenesis and Cell Migration; Evolution and the Diversification of Cerebellar Nuclei; Cerebellar Nuclei and Disease; Future Perspectives on Cerebellar Nucleus Development; References; Motor Circuit Abnormalities During Cerebellar Development; Introduction; Structure of the Cerebellum; Development of the Cerebellar Circuit; The Role of Cerebellar Development in Ataxia, a Classical Cerebellar Movement Disorder; SCA1 (Spinocerebellar Ataxia Type 1)
PCs as Project Managers of Cerebellar Cytoarchitecture and Connectivity Cerebellar Anlagen and Germinal Zones; Establishment of Neurogenic Microdomains for GABAergic Progenitors; The Regulation of PC Progenitor Specification and Commitment; Ebf2 and PC Subtype Specification; Embryonic PC Cluster Formation; From Clusters to Zones and Stripes; Conclusions; References; Cerebellar Developmental Disorders and Cerebellar Nuclei; What Are Cerebellar Nuclei?; Cellular Anatomy and Diversity; Outputs of the Cerebellar Nuclei; Inputs to Cerebellar Nuclei; Development of Cerebellar Nuclei
SCA6 (Spinocerebellar Ataxia Type 6) Car8wdl (The waddles Spontaneous Mutant Mouse); L7Cre; Vgatflox/flox (Conditional Genetic Silencing of Purkinje Cell Neurotransmission); Cerebellar Development and Non-motor Disorders; References; Developmental Disorders of the Cerebellum and Neurotrophic Factors; Introduction; Neurotrophic Factors; Neurotrophins; Transforming Growth Factor-Beta Superfamily; Neurotrophic Cytokines; Neurotrophic Factors and Cerebellar Development; Cerebellum and Neurodevelopmental Disorders; Attention Deficit Hyperactivity Disorder; Autism Spectrum Disorders
Summary The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families
Notes Includes index
Online resource; title from PDF title page (SpringerLink, viewed August 7, 2017)
Subject Cerebellum -- Diseases.
Cerebellum -- Growth.
Cerebellum -- growth & development.
Form Electronic book
Author Marzban, Hassan, editor
ISBN 3319597493 (electronic bk.)
9783319597492 (electronic bk.)