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Cytochrome P-450 Oxygenase -- See Cytochrome P-450 Enzyme System


A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism
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Cytochrome P-450 -- Physiological effect   3
Cytochrome P-450 -- Structure : Cytochromes P450 : structure, function and mechanism / David F.V. Lewis  1996 1
 

Cytochrome P-450 Superfamily -- See Cytochrome P-450 Enzyme System


A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism
  1
Cytochrome P-450 -- Technique. : Cytochrome P450 / edited by Michael R. Waterman, Eric F. Johnson  2002 1
Cytochrome P-450 -- Therapeutic use   2
Cytochrome P-450 -- Toxicology : Cytochromes P450 : role in the metabolism and toxicity of drugs and other xenobiotics / edited by Costas Ioannides  2008 1
 

Cytochrome P450 -- See Cytochrome P-450 Enzyme System


A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism
  1
 

Cytochrome P450 2B6 -- See Cytochrome P-450 CYP2B6


A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is due to the high rate of GENETIC POLYMORPHISMS. Examples of drugs metabolized by CYP2B6 include BUPROPION; efavirenz; CYCLOPHOSPHAMIDE; and MEPERIDINE
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Cytochrome P450 2D6 -- See Cytochrome P-450 CYP2D6


A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population
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Cytochrome P450 2E1 -- See Cytochrome P-450 CYP2E1


An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse
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Cytochrome p450 Families -- See Cytochrome P-450 Enzyme System


A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism
  1
 

Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 -- See Cytochrome P-450 CYP2C8


A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
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Cytochrome P450 MP-4 -- See Cytochrome P-450 CYP2C9


A cytochrome P-450 subtype that has specificity for acidic XENOBIOTICS. It oxidizes a broad range of important clinical drugs that fall under the categories of NONSTEROIDAL ANTI-INFLAMMATORY AGENTS; HYPOGLYCEMIC AGENTS; ANTCOAGULANTS; and DIURETICS
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Cytochrome P450 MP-8 -- See Cytochrome P-450 CYP2C9


A cytochrome P-450 subtype that has specificity for acidic XENOBIOTICS. It oxidizes a broad range of important clinical drugs that fall under the categories of NONSTEROIDAL ANTI-INFLAMMATORY AGENTS; HYPOGLYCEMIC AGENTS; ANTCOAGULANTS; and DIURETICS
  1
 

Cytochrome P450 MP-20 -- See Cytochrome P-450 CYP2C8


A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE
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Cytochrome P450 PB-1 -- See Cytochrome P-450 CYP2C9


A cytochrome P-450 subtype that has specificity for acidic XENOBIOTICS. It oxidizes a broad range of important clinical drugs that fall under the categories of NONSTEROIDAL ANTI-INFLAMMATORY AGENTS; HYPOGLYCEMIC AGENTS; ANTCOAGULANTS; and DIURETICS
  1
 

Cytochrome P450 Superfamily -- See Cytochrome P-450 Enzyme System


A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism
  1
 

Cytochromes -- See Also the narrower term Cytochrome P-450


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Cytochromes. : Mitochondrial oxidative phosphorylation : nuclear-encoded genes, enzyme regulation, and pathophysiology / edited by Bernhard Kadenbach  2012 1
Cytochromes c : Mitochondrial oxidative phosphorylation : nuclear-encoded genes, enzyme regulation, and pathophysiology / edited by Bernhard Kadenbach  2012 1
Cytochromes -- Technique. : Cytochrome P450 / edited by Michael R. Waterman, Eric F. Johnson  2002 1
 

Cytochromes Type c -- See Cytochrome c Group


A group of cytochromes with covalent thioether linkages between either or both of the vinyl side chains of protoheme and the protein. (Enzyme Nomenclature, 1992, p539)
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Cytochroom P450.   2
 

Cytodiagnoses -- See Cytodiagnosis


Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)
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  Cytodiagnosis -- 6 Related Subjects   6
Cytodiagnosis.   65
Abdomen -- Cancer -- Cytodiagnosis : Transabdominal fine-needle aspiration biopsy : a colour atlas and monograph (with CD-ROM) / Grace Chia-yu Hsu Yang, Liang-Che Tao  2007 1
Adenocarcinoma -- Cytodiagnosis : Endometrial adenocarcinoma : prevention and early diagnosis / Matías Jiménez-Ayala, Beatriz Jiménez-Ayala Portillo ; including contributions by Enrique Iglesias Goy, Mar Rios Vallejo  2008 1
Asbestosis -- Complications -- Cytodiagnosis   2
Cytodiagnosis -- Atlases   11
Cytodiagnosis -- Australia. : Recruitment for cervical screening : a review of the literature / Judith A.Y. Straton  1996 1
Bladder -- Diseases -- Cytodiagnosis   3
Bladder -- Diseases -- Cytodiagnosis -- Handbooks, manuals, etc : Endoscopic diagnosis and treatment in urinary bladder pathology : handbook of endourology / edited by Petrisor A. Geavlete  2016 1
Bladder -- Tumors -- Cytodiagnosis   2
Breast -- Cancer -- Cytodiagnosis : Biopsy interpretation of the breast / Stuart J. Schnitt, Laura C. Collins  2017 1
Breast -- Diseases -- Cytodiagnosis   2
Cancer -- Cytodiagnosis.   5
Cytodiagnosis -- Case studies : Cytopathology case review / Christopher J. VandenBussche and Syed Z. Ali  2015 1
Cervix uteri -- Cancer -- Cytodiagnosis.   7
Cervix uteri -- Cancer -- Cytodiagnosis -- Standards -- Australia. : Performance standards for Australian laboratories reporting cervical cytology / National Cervical Screening Program  1996 1
Cervix utery -- Cancer -- Cytodiagnosis   2
Colon (Anatomy) -- Cancer -- Cytodiagnosis : Colitis : a practical approach to colon biopsy interpretation / Karel Geboes, Sonia Nemolato, Maria Leo, Gavino Faa  2014 1
Colon (Anatomy) -- Diseases -- Cytodiagnosis : Colitis : a practical approach to colon biopsy interpretation / Karel Geboes, Sonia Nemolato, Maria Leo, Gavino Faa  2014 1
Endometrium -- Cancer -- Cytodiagnosis   2
Endometrium -- Diseases -- Cytodiagnosis : Diagnosis of endometrial biopsies and curettings : a practical approach / Michael T. Mazur, Robert J. Kurman  2005 1
Eye -- Tumors -- Cytodiagnosis : FNA cytology of ophthalmic tumors / volume editors, Charles V. Biscotti, Arun D. Singh  2012 1
Gastrointestinal system -- Cancer -- Cytodiagnosis : Cytology of the mediastinum and gut via endoscopic ultrasound-guided aspiration / Ricardo H. Bardales, editor  2015 1
Generative organs, Female -- Diseases -- Cytodiagnosis : Atlas of gynecologic cytology / Grace T. McKee  2004 1
Generative organs, Female -- Diseases -- Cytodiagnosis -- Atlases   2
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