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Book Cover
Streaming video
Author Burn, John, (University of Newcastle, UK), speaker

Title Mismatch repair deficient cancers diagnosis, treatment and prevention / John Burn
Published London : Henry Stewart Talks, 2014
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (44 min.) : color, sound)
Series Molecular genetics of human disease, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Molecular genetics of human disease
Contents Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Aspirin.
Cancer -- Genetic aspects.
Colon (Anatomy) -- Cancer -- Genetic aspects.
Colon (Anatomy) -- Cancer -- Treatment.
Medical genetics.
Molecular genetics.
Rectum -- Cancer -- Genetic aspects.
Rectum -- Cancer -- Treatment.
Aspirin -- therapeutic use.
Colorectal Neoplasms -- diagnosis.
Colorectal Neoplasms -- genetics.
Colorectal Neoplasms -- therapy.
Colorectal Neoplasms, Hereditary Nonpolyposis.
DNA Mismatch Repair.
Genetics, Medical.
Microsatellite Instability.
Microsatellite Repeats.
Genre/Form Video recordings.
Form Streaming video