Front Cover; The SV40 Replicon Model for Analysis of Anticancer Drugs; Copyright Page; Contents; Chapter 1. Papovavirus Models for Mammalian Replicons; Chapter 2. Analysis of SV40 DNA Replication Intermediates; Chapter 3. Catastrophic Failure of DNA Replication Forks: Structural and Recombinational Pathways; Chapter 4. Topoisomerase II and Termination of DNA Replication; Chapter 5. DNA Damaging Agents; Chapter 6. Drug Discovery and Evaluation with SV40; Chapter 7. SV40 In Vitro DNA Replication: A Potential Model For Studying Anticancer Drug Action
Summary
This book provides the most up-to-date review of the simian virus 40 (SV40) minichromosome as a model for the mammalian chromosome in studies of DNA replication. It focuses on disruption of DNA replication by anticancer drugs and DNA-damaging agents. There is a strong emphasis on the unique advantages of SV40 as an experimental system for the analysis of these classes of anticancer drug mechanisms. The new high-resolution gel electrophoresis methods for the analysis of SV40 DNA replication are covered in detail to aid readers in designing and interpreting similar experiments
