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Author Capek, Ignác, author.

Title DNA engineered noble metal nanoparticles : fundamentals and state-of-the-art-of nanobiotechnology / Ignác Capek
Published Hoboken, New Jersey : John Wiley and Sons, Inc. ; Salem, Massachusetts : Scrivener Publishing LLC, 2015
Online access available from:
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Description 1 online resource
Series Advanced materials series
Advanced materials series (Scrivener Publishing)
Contents Nucleic acids -- Noble metal nanoparticles -- DNA-based conjugates -- DNA-noble metal nanoparticle conjugates -- DNA-gold nanoparticle conjugates -- PNA-noble metal nanoparticles conjugates -- DNA-silver nanoparticles conjugates -- The structure of DNA-noble metal nanoparticles conjugates -- Photochemical and photophysical events -- Nanoparticle therapeutics
Summary There is a growing interest in the use of nanoparticles modified with DNAs, viruses, peptides and proteins for the rational design of nanostructured functional materials and their use in biosensor applications. The challenge is to control the organization of biomolecules on nanoparticles while retaining their biological activity as potential chemical and gene therapeutics. These noble metal nanoparticles/biomolecules conjugates have specific properties and therefore they are attractive materials for nanotechnology in biochemistry and medicine. In this book, the author review work performed dealing with the DNA structure and functionalities, interactions between DNA, noble metal nanoparticles, surface active agents, solvents and other additives. Particular attention is given to how the DNA's chain length and the DNA conformation affect the interaction and structure of the nanoconjugates and nanostructures that are formed. Also discussed are the recent advances in the preparation, characterization, and applications of noble metal nanoparticles that are conjugated with DNA aptamers and oligomers. The advantages and disadvantages of functionalized nanoparticles through various detection modes are highlighted, including colorimetry, fluorescence, electrochemistry, SPR, and, mass spectrometry for the detection of small molecules and biomolecules. The functionalized noble metal nanoparticles are selective and sensitive for the analytes, showing their great potential in biosensing. Furthermore, this book reviews recent progress in the area of DNA-noble metal nanoparticles based artificial nanostructures, that is, the preparation, collective properties, and applications of various DNA-based nanostructures are also described
Bibliography Includes bibliographical references and index
Notes Print version record and CIP data provided by publisher
Subject Bioconjugates.
DNA -- Biotechnology
Precious metals -- Biotechnology
DNA -- chemistry.
Gold -- chemistry.
Metal Nanoparticles.
Silver -- chemistry.
SCIENCE -- Life Sciences -- Biology.
SCIENCE -- Life Sciences -- Microbiology.
Form Electronic book
LC no. 2015008514
ISBN 1118072146