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Author Ouldridge, Thomas E.

Title Coarse-grained modelling of DNA and DNA self-assembly / Thomas E. Ouldridge
Published Berlin ; New York : Springer, [2012]
©2012
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Description 1 online resource : illustrations
Series Springer theses, 2190-5053
Springer theses.
Contents Introduction -- A Novel DNA Model -- Methods -- Finite Size Effects -- Stuctural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker -- Conclusions
Summary This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology
Analysis Nanotechnology
Physics
Biophysics and Biological Physics
Statistical Physics, Dynamical Systems and Complexity
Soft and Granular Matter, Complex Fluids and Microfluidics
Notes Ph. D. University of Oxford
Bibliography Includes bibliographical references
Subject DNA -- Computer simulation.
Nanotechnology.
Genre/Form Academic theses.
Form Electronic book
LC no. 2012942795
ISBN 9783642305177 (electronic bk.)
3642305172 (electronic bk.)
3642305164 (print)
9783642305160 (print)