| Description |
1 online resource : illustrations |
| Series |
Springer theses, 2190-5053 |
|
Springer theses.
|
| Contents |
Introduction -- A Novel DNA Model -- Methods -- Finite Size Effects -- Stuctural and Mechanical Properties of Model DNA -- Thermodynamic Properties of Model DNA -- Modelling DNA Tweezers -- Modelling a DNA Walker -- Conclusions |
| Summary |
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology |
| Analysis |
Nanotechnology |
|
Physics |
|
Biophysics and Biological Physics |
|
Statistical Physics, Dynamical Systems and Complexity |
|
Soft and Granular Matter, Complex Fluids and Microfluidics |
| Notes |
Ph. D. University of Oxford |
| Bibliography |
Includes bibliographical references |
| Subject |
DNA -- Computer simulation.
|
|
Nanotechnology.
|
| Genre/Form |
Academic theses.
|
| Form |
Electronic book
|
| LC no. |
2012942795 |
| ISBN |
9783642305177 (electronic bk.) |
|
3642305172 (electronic bk.) |
|
3642305164 (print) |
|
9783642305160 (print) |
|
