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Title Synthetic nucleic acids as inhibitors of gene expression : mechanisms, applications, and therapeutics implications / edited by Levon Michael Khachigian
Published Boca Raton : CRC Press, [2005]
Online access available from:
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Description 1 online resource (182 pages) : illustrations (some color)
Contents Therapeutic application of ribozymes for cardiovascular disease -- Development of ribozymes as cancer therapeutics -- RNA interference: a technology based on an ancient gene silencing pathway -- RNA-cleaving DNA enzymes in gene silencing: room for improvement? -- Deoxyribozymes and medical innovation -- Effect of modifications on the intracellular activity of a DNA enzyme -- Potential therapeutic applications of DNA enzymes and siRNAs against viral and cellular genes -- Use of DNAzymes for target gene validation -- DNAzymes targeting immediate-early genes as inhibitors of angiogenesis and restenosis -- Decoy oligodeoxynucleotides as viable pharmaceutical drugs
Bibliography Includes bibliographical references and index
Notes Print version record
Subject Nucleic Acids -- physiology
Nucleic Acids -- therapeutic use
DNA, Catalytic
Gene Silencing -- drug effects
RNA, Catalytic
Catalytic RNA
Genetic regulation
Repressors, Genetic
BIOGRAPHY & AUTOBIOGRAPHY -- Science & Technology.
Catalytic RNA.
Genetic regulation.
Repressors, Genetic.
SCIENCE -- Life Sciences -- Molecular Biology.
Form Electronic book
Author Khachigian, Levon
LC no. 2004054474
ISBN 1420037897