Down (Northern Ireland) -- Directories. : County Down guide and directory, including the borough of Newry : a book for manufacturers, merchants, traders, land-owners, farmers, tourists, anglers, and sportsmen generally / by George Henry Bassett
Down (Northern Ireland) -- History. : County Down guide and directory, including the borough of Newry : a book for manufacturers, merchants, traders, land-owners, farmers, tourists, anglers, and sportsmen generally / by George Henry Bassett
A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)