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Book Cover
Streaming video
Author Kingston, Robert (Harvard University, USA), speaker

Title Maintaining the silenced state of master regulatory genes during development / Bob Kingston
Published London : Henry Stewart Talks, 2014
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (54 min.) : color, sound)
Series Epigenetics, chromatin, transcription and cancer, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer
Contents Contents: Gene repression in cell division -- Early homeotic gene expression patterns -- The polycomb group -- Mutants of polycomb fail to maintain repression -- Transcriptional memory -- Core functional PcG complexes -- Regulation of PRC2 in drosophila and humans -- PRC2 core subunits in humans -- Prominent modifications that can occur -- Chromodomains bind H3 tail marks -- Differential chromodomain binding -- Targeting of the PcG complexes -- Drosophila PREs are bound by PHO -- Mechanisms involved in targeting -- Mammalian HOX clusters are a key PRC1 target -- Human D11.12 is similar to fly PREs -- CpG islands and long non-coding RNAs -- Small RNAs specifying repression -- Noncoding RNAs influence chromatin structure -- Mode of repression -- How are genes silenced? -- PRC1 in compaction and ubiquitylation -- Nucleosome dynamics -- Characteristics of the compaction domain -- Gene silencing by chromatin compaction -- The SIR complex and mating type silencing -- Structural rearrangements in NCP and BAH -- Folding events in Sir3 BAH/NCP complex -- The nucleosome as a silencing machinery -- Epigenetic memory
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
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Subject Chromosomal proteins.
Developmental genetics.
Gene silencing.
Genetic regulation.
Drosophila Proteins -- metabolism.
Epigenesis, Genetic.
Gene Expression Regulation, Developmental.
Gene Silencing.
Polycomb-Group Proteins.
Repressor Proteins -- metabolism.
Transcription Factors -- metabolism.
Genre/Form Video recordings.
Form Streaming video