| Description |
1 online resource (xiii, 489 pages) : illustrations |
| Series |
Drugs and the pharmaceutical sciences ; v. 196 |
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Drugs and the pharmaceutical sciences ; v. 196.
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| Contents |
Key factors for successful high-throughput screening / John G. Houston -- Critical components in high-throughput screening : challenges and new trends / Litao Zhang, Martyn N. Banks, and John G. Houston -- Hit-to-probe-to-lead optimization strategies : a biology perspective to conquer the valley of death / Anuradha Roy [and others] -- Signal detection platforms for screening in drug discovery / Ramakrishna Seethala -- Proteomic analysis in drug discovery / Haiteng Deng, Yang Xu, and Linqi Zhang -- Screening and characterization of g-protein-coupled receptor ligands for drug discovery / Ge Zhang and Mary Ellen Cvijic |
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Nuclear hormone receptor screening in drug discovery / Ramakrishna Seethala and Litao Zhang -- Emerging novel high-throughput screening technologies for cell-based assays / ILona Kariv [and others] -- In vitro strategies for ion channel screening in drug discovery / Ravikumar Peri, Mark Bowlby, and John Dunlop -- Wheat from chaff : general and mechanistic triage of screening hits for enzyme targets / Mark R. Harpel -- Protein kinases and phosphatases / Pirthipal Singh -- MicroRNA strategies in drug discovery / Wishva B. Herath -- Strategies for screening of biologic therapeutics / Ian Foltz and Francesca Civoli |
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Cryopreserved cells in functional cell-based HTS assays / Geetha Shankar and Kirk McMillan -- High-content screening with a special emphasis on cytotoxicity and cell health measurements Ralph J. Garippa and Ann F. Hoffman -- Effective application of drug metabolism and pharmacokinetics in drug discovery Sharon Diamond and Swanny Yeleswaram -- Compound management for drug discovery : an overview Moneesh Chatterjee and Martyn N. Banks -- Practical approach to quantitative high throughput screening Wei Zheng, Ke Liu, and James Inglese -- Enabling the large-scale analysis of quantitative high-throughput screening data Noel T. Southall [and others] -- Application of nanobiotechnologies for drug discovery / K.K. Jain |
| Summary |
Building upon the foundation of basics discussed in the previous edition, the Second Edition provides a more in-depth look at the latest methods and technologies of advanced drug screening, an essential function of drug discovery |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002. http://purl.oclc.org/DLF/benchrepro0212 MiAaHDL |
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Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL |
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Print version record |
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digitized 2011 HathiTrust Digital Library committed to preserve pda MiAaHDL |
| Subject |
Drug development -- Handbooks, manuals, etc
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Drugs -- Testing -- Handbooks, manuals, etc
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Drug Evaluation, Preclinical -- methods
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MEDICAL -- Drug Guides.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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MEDICAL -- Nursing -- Pharmacology.
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Drug development
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Drugs -- Testing
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| Genre/Form |
Electronic book
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handbooks.
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Handbooks and manuals
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Handbooks and manuals.
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Guides et manuels.
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| Form |
Electronic book
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| Author |
Seethala, Ramakrishna, 1947-
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Zhang, Litao.
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| ISBN |
9781420061697 |
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1420061690 |
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