| Description |
1 online resource (2 volumes (lviii, 2071 pages)) : illustrations |
| Series |
Springer reference |
|
Springer reference.
|
| Contents |
Introduction strategies in drug discovery and evaluation -- Cardiovascular activity -- Pharmacological assays in thrombosis and haemostasis -- Activity on urinary tract -- Respiratory activity -- Psychotropic and neurotropic activity -- Drug effects on learning and memory -- Effects on peripheral nerve function -- Analgesic, anti-inflammatory, and anti-pyretic activity -- Antiarthrotic and immunomodulatory activity -- Activity on the gastrointestinal tract -- Antidiabetic activity -- Anti-obesity activity -- Anti-atherosclerotic activity -- Endocrinology -- Ophthalmologic activity -- Pharmacological models in dermatology -- Guidelines for the care and use of laboratory animals -- Index |
| Summary |
The rapid progress in biology will continue to change the methodological approach to drug discovery in the coming years. Electronic media will continuously help researchers to access and share information. It is, however, becoming more and more evident that many young pharmacologists have only limited training in classical pharmacological methodologies. These long-standing and still highly relevant methods are simply not available in the electronic databases. Drug Discovery and Evaluation:Pharmacological Assays bridges this gap by comprehensively covering the pharmacological methods that have been utilized successfully for more than a hundred years as well as the latest technologies. The classical methods and the newest technologies, all in one book! The 3rd edition of this successful reference book contains an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Effects covered include cardiovascular, analgesic, endocrine, psychotropic, respiratory, renal, and immunomodulatory activities. Each of the more than 1000 assays comprises a detailed protocol outlining the purpose and rationale of the method, a critical assessment of the results and their pharmacological and clinical relevance. In addition, animal models of rare diseases are described. For this third edition, all existing chapters have been revised and completely updated. A large number of assays were added: we are now publishing two volumes. Sections that have been specifically enlarged include - Pharmacological assays in thrombosis and haemostasis (formerly called activity of blood constituents), - Antidiabetic activity (includes completely new chapters such as Biochemical Methods in Diabetology), - Anti-atherosclerotic activity. Audience: Pharmacologists and Pharmacists in Academia and Industry |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| In |
Springer e-books |
| Subject |
Pharmacology, Experimental.
|
|
Drugs -- Design.
|
|
Drugs -- Testing.
|
|
Drug Design
|
|
Drug Evaluation -- methods
|
|
Drug Evaluation, Preclinical -- methods
|
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Biomédecine.
|
|
Sciences de la vie.
|
|
Drugs -- Design
|
|
Drugs -- Testing
|
|
Pharmacology, Experimental
|
| Genre/Form |
Electronic books
|
| Form |
Electronic book
|
| Author |
Vogel, H. Gerhard, 1927-
|
| ISBN |
9783540709954 |
|
3540709959 |
|
9783540714200 |
|
3540714200 |
|
9783540714194 |
|
3540714197 |
|
