I. Background and basic science -- Erythropoiesis : an overview / Lyonel G. Israels and Esther D. Israels -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin / MaryAnn Foote -- Structural basis for the signal transduction of erythropoietin / Timothy Osslund and Rashid Syed -- Molecular biology of the erythropoietin receptor in hematopoietic and non-hematopoietic tissues / Christof Dame -- Erythropoietin receptor signaling processes / Saghi Ghaffari [and others] -- Clinical pharmacokinetic properties of rHuEPO : a review / Anne C. Heatherington -- Biology of erythropoietin / Graham Molineux -- Commercial production of recombinant erythropoietins / Alice S. Chuck [and others] -- II. Clinical use of recombinant erythropoietins -- Use of recombinant erythropoietins in the setting of renal disease / lain C. Macdougall -- Erythropoietic therapy in the practice of oncology / John Glaspy -- Use of recombinant erythropoietins for the treatment of anemia of chronic disease / Robert T Means, Jr. -- Use of erythropoietins in the surgical setting / Fred D. Cushner -- Abuse of recombinant erythropoietins by athletes / Don H. Catlin, Caroline K. Hatton, and Francoise Lasne -- Antibodies to endogenous and recombinant erythropoietin / Patrick Mayeux and Nicole Casadevall -- New molecules and formulations of recombinant human erythropoietin / Steven G. Elliott
Summary
"This volume is a one-source guide to the most current information about red blood cell formation and the action of recombinant human erythropoietins. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed." "It is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators."--Jacket
