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Title Modeling dose-response microarray data in early drug development experiments using R : order-restricted analysis of mircoarray data / Dan Lin [and others], editors
Published Berlin ; London : Springer, 2012

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Description 1 online resource
Series Use R!
Use R!
Contents 880-01 Part 1. Dose-response Modeling: An Introduction -- Estimation Under Order Restrictions / Ziv Shkedy, Dhammika Amaratunga and Marc Aerts -- Testing of Equality of Means Against Ordered Alternatives / Ziv Shkedy, Dhammika Amaratunga and Dan Lin -- Nonlinear Modeling of Dose-Response Data / Roel Straetemans -- Introduction / Dan Lin, Willem Talloen, Luc Bijnens, Hinrich W.H. Göhlmann and Dhammika Amaratunga, et al. -- Part 2. Dose-response Microarray Experiments -- Functional Genomic Dose-Response Experiments / Luc Bijnens, Hinrich W.H. Göhlmann, Dan Lin, Willem Talloen and Tim Perrera, et al. -- Adjustment for Multiplicity / Daniel Yekutieli, Dan Lin, Ziv Shkedy and Dhammika Amaratunga -- Single Contrast Tests / Dan Lin, Ziv Shkedy, Daniel Yekutieli, Tomasz Burzykowski and Hinrich W.H. Göhlmann, et al. -- Significance Analysis of Dose-Response Microarray Data / Dan Lin, Ziv Shkedy, Hinrich W.H. Göhlmann, An De Bondt and Luc Bijnens, et al. -- [delta]-Clustering of Monotone Profiles / Adetayo Kasim, Suzy Van Sanden, Martin Otava, Sepp Hochreiter and Djork-Arné Clevert, et al
880-01/(S Machine generated contents note: 1. Introduction / Roel Straetemans -- pt. I Dose-Response Modeling: An Introduction -- 2. Estimation Under Order Restrictions / Marc Aerts -- 3. Testing of Equality of Means Against Ordered Alternatives / Dan Lin -- 4. Nonlinear Modeling of Dose-Response Data / Roel Straetemans -- pt. II Dose-Response Microarray Experiments -- 5. Functional Genomic Dose-Response Experiments / Pieter Peeters -- 6. Adjustment for Multiplicity / Dhammika Amaratunga -- 7. Single Contrast Tests / Luc Bijnens -- 8. Significance Analysis of Dose-Response Microarray Data / Willem Talloen -- 9. δ-Clustering of Monotone Profiles / Dan Lin -- 10. Classification of Monotone Gene Profiles Using Information Theory Selection Methods / Marc Aerts -- 11. Beyond the Simple Order Alternatives / Ziv Shkedy -- 12. Gene Set Analysis as a Means of Facilitating the Interpretation of Microarray Results / Dhammika Amaratunga -- 13. Estimation and Inference Under Simple Order Restrictions: Hierarchical Bayesian Approach / Bernet S. Kato -- 14. Model-Based Approaches / Jose Pinheiro -- 15. Multiple Contrast Tests for Testing Dose-Response Relationships Under Order-Restricted Alternatives / Frank Bretz -- 16. Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test / Ludwig A. Hothorn -- 17. Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate / Ludwig A. Hothorn -- 18. Interfaces for Analyzing Dose-Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN / Tobias Verbeke
Classification of Monotone Gene Profiles Using Information Theory Selection Methods / Dan Lin, Ziv Shkedy and Marc Aerts -- Beyond the Simple Order Alternatives / Dan Lin and Ziv Shkedy -- Gene Set Analysis as a Means of Facilitating the Interpretation of Microarray Results / Nandini Raghavan, An De Bondt, Tobias Verbeke and Dhammika Amaratunga -- Estimation and Inference Under Simple Order Restrictions: Hierarchical Bayesian Approach / Adetayo Kasim, Ziv Shkedy and Bernet S. Kato -- Model-Based Approaches / Setia Pramana, Ziv Shkedy, Hinrich W.H. Göhlmann, Willem Talloen and An De Bondt, et al. -- Multiple Contrast Tests for Testing Dose-Response Relationships Under Order-Restricted Alternatives / Dan Lin, Ludwig A. Hothorn, Gemechis D. Djira and Frank Bretz -- Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test / Dan Lin, Gemechis D. Djira, Ziv Shkedy, Tomasz Burzykowski and Ludwig A. Hothorn -- Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate / Dan Lin, Daniel Yekutieli, Gemechis D. Djira and Ludwig A. Hothorn -- Interfaces for Analyzing Dose-Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN / Setia Pramana, Philippe Haldermans and Tobias Verbeke
Summary This book focuses on the analysis of dose-response microarray data in pharmaceutical setting, the goal being to cover this important topic for early drug development and to provide user-friendly R packages that can be used to analyze dose-response microarray data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as the likelihood ratio test and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book. Methodological topics discussed include: · Multiplicity adjustment · Test statistics and testing procedures for the analysis of dose-response microarray data · Resampling-based inference and use of the SAM method at the presence of small-variance genes in the data · Identification and classification of dose-response curve shapes · Clustering of order restricted (but not necessarily monotone) dose-response profiles · Hierarchical Bayesian models and non-linear models for dose-response microarray data · Multiple contrast tests All methodological issues in the book are illustrated using four 'real-world' examples of dose-response microarray datasets from early drug development experiments
Analysis statistiek
statistics
bioinformatics
toegepaste statistiek
applied statistics
farmacologie
pharmacology
computertechnieken
computer techniques
levenswetenschappen
life sciences
biostatistiek
biostatistics
Statistics (General)
Statistiek (algemeen)
Notes Print version record
Subject Drugs -- Dose-response relationship -- Computer simulation
Drugs -- Testing -- Computer simulation
DNA microarrays.
Drugs.
Drugs -- Dose-response relationship.
Pharmaceutical Preparations
Dose-Response Relationship, Drug
Microarray Analysis
MEDICAL -- Drug Guides.
MEDICAL -- Nursing -- Pharmacology.
MEDICAL -- Pharmacology.
MEDICAL -- Pharmacy.
Medicamentos -- Verificación
Medicamentos -- Simulación por ordenador
Drugs -- Dose-response relationship
Drugs
DNA microarrays
Form Electronic book
Author Lin, Dan (Medical researcher)
ISBN 9783642240072
3642240070