Description |
1 online resource |
Series |
Use R! |
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Use R!
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Contents |
880-01 Part 1. Dose-response Modeling: An Introduction -- Estimation Under Order Restrictions / Ziv Shkedy, Dhammika Amaratunga and Marc Aerts -- Testing of Equality of Means Against Ordered Alternatives / Ziv Shkedy, Dhammika Amaratunga and Dan Lin -- Nonlinear Modeling of Dose-Response Data / Roel Straetemans -- Introduction / Dan Lin, Willem Talloen, Luc Bijnens, Hinrich W.H. Göhlmann and Dhammika Amaratunga, et al. -- Part 2. Dose-response Microarray Experiments -- Functional Genomic Dose-Response Experiments / Luc Bijnens, Hinrich W.H. Göhlmann, Dan Lin, Willem Talloen and Tim Perrera, et al. -- Adjustment for Multiplicity / Daniel Yekutieli, Dan Lin, Ziv Shkedy and Dhammika Amaratunga -- Single Contrast Tests / Dan Lin, Ziv Shkedy, Daniel Yekutieli, Tomasz Burzykowski and Hinrich W.H. Göhlmann, et al. -- Significance Analysis of Dose-Response Microarray Data / Dan Lin, Ziv Shkedy, Hinrich W.H. Göhlmann, An De Bondt and Luc Bijnens, et al. -- [delta]-Clustering of Monotone Profiles / Adetayo Kasim, Suzy Van Sanden, Martin Otava, Sepp Hochreiter and Djork-Arné Clevert, et al |
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880-01/(S Machine generated contents note: 1. Introduction / Roel Straetemans -- pt. I Dose-Response Modeling: An Introduction -- 2. Estimation Under Order Restrictions / Marc Aerts -- 3. Testing of Equality of Means Against Ordered Alternatives / Dan Lin -- 4. Nonlinear Modeling of Dose-Response Data / Roel Straetemans -- pt. II Dose-Response Microarray Experiments -- 5. Functional Genomic Dose-Response Experiments / Pieter Peeters -- 6. Adjustment for Multiplicity / Dhammika Amaratunga -- 7. Single Contrast Tests / Luc Bijnens -- 8. Significance Analysis of Dose-Response Microarray Data / Willem Talloen -- 9. δ-Clustering of Monotone Profiles / Dan Lin -- 10. Classification of Monotone Gene Profiles Using Information Theory Selection Methods / Marc Aerts -- 11. Beyond the Simple Order Alternatives / Ziv Shkedy -- 12. Gene Set Analysis as a Means of Facilitating the Interpretation of Microarray Results / Dhammika Amaratunga -- 13. Estimation and Inference Under Simple Order Restrictions: Hierarchical Bayesian Approach / Bernet S. Kato -- 14. Model-Based Approaches / Jose Pinheiro -- 15. Multiple Contrast Tests for Testing Dose-Response Relationships Under Order-Restricted Alternatives / Frank Bretz -- 16. Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test / Ludwig A. Hothorn -- 17. Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate / Ludwig A. Hothorn -- 18. Interfaces for Analyzing Dose-Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN / Tobias Verbeke |
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Classification of Monotone Gene Profiles Using Information Theory Selection Methods / Dan Lin, Ziv Shkedy and Marc Aerts -- Beyond the Simple Order Alternatives / Dan Lin and Ziv Shkedy -- Gene Set Analysis as a Means of Facilitating the Interpretation of Microarray Results / Nandini Raghavan, An De Bondt, Tobias Verbeke and Dhammika Amaratunga -- Estimation and Inference Under Simple Order Restrictions: Hierarchical Bayesian Approach / Adetayo Kasim, Ziv Shkedy and Bernet S. Kato -- Model-Based Approaches / Setia Pramana, Ziv Shkedy, Hinrich W.H. Göhlmann, Willem Talloen and An De Bondt, et al. -- Multiple Contrast Tests for Testing Dose-Response Relationships Under Order-Restricted Alternatives / Dan Lin, Ludwig A. Hothorn, Gemechis D. Djira and Frank Bretz -- Simultaneous Inferences for Ratio Parameters Using Multiple Contrasts Test / Dan Lin, Gemechis D. Djira, Ziv Shkedy, Tomasz Burzykowski and Ludwig A. Hothorn -- Multiple Confidence Intervals for Selected Ratio Parameters Adjusted for the False Coverage-Statement Rate / Dan Lin, Daniel Yekutieli, Gemechis D. Djira and Ludwig A. Hothorn -- Interfaces for Analyzing Dose-Response Studies in Microarray Experiments: IsoGeneGUI and ORIOGEN / Setia Pramana, Philippe Haldermans and Tobias Verbeke |
Summary |
This book focuses on the analysis of dose-response microarray data in pharmaceutical setting, the goal being to cover this important topic for early drug development and to provide user-friendly R packages that can be used to analyze dose-response microarray data. It is intended for biostatisticians and bioinformaticians in the pharmaceutical industry, biologists, and biostatistics/bioinformatics graduate students. Part I of the book is an introduction, in which we discuss the dose-response setting and the problem of estimating normal means under order restrictions. In particular, we discuss the pooled-adjacent-violator (PAV) algorithm and isotonic regression, as well as the likelihood ratio test and non-linear parametric models, which are used in the second part of the book. Part II is the core of the book. Methodological topics discussed include: · Multiplicity adjustment · Test statistics and testing procedures for the analysis of dose-response microarray data · Resampling-based inference and use of the SAM method at the presence of small-variance genes in the data · Identification and classification of dose-response curve shapes · Clustering of order restricted (but not necessarily monotone) dose-response profiles · Hierarchical Bayesian models and non-linear models for dose-response microarray data · Multiple contrast tests All methodological issues in the book are illustrated using four 'real-world' examples of dose-response microarray datasets from early drug development experiments |
Analysis |
statistiek |
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statistics |
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bioinformatics |
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toegepaste statistiek |
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applied statistics |
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farmacologie |
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pharmacology |
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computertechnieken |
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computer techniques |
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levenswetenschappen |
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life sciences |
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biostatistiek |
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biostatistics |
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Statistics (General) |
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Statistiek (algemeen) |
Notes |
Print version record |
Subject |
Drugs -- Dose-response relationship -- Computer simulation
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Drugs -- Testing -- Computer simulation
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DNA microarrays.
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Drugs.
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Drugs -- Dose-response relationship.
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Pharmaceutical Preparations
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Dose-Response Relationship, Drug
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Microarray Analysis
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MEDICAL -- Drug Guides.
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MEDICAL -- Nursing -- Pharmacology.
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MEDICAL -- Pharmacology.
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MEDICAL -- Pharmacy.
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Medicamentos -- Verificación
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Medicamentos -- Simulación por ordenador
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Drugs -- Dose-response relationship
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Drugs
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DNA microarrays
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Form |
Electronic book
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Author |
Lin, Dan (Medical researcher)
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ISBN |
9783642240072 |
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3642240070 |
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