Title A prescription for change : the looming crisis in drug development / Michael S. Kinch

Published Chapel Hill : The University of North Carolina Press, 2016

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Description 1 online resource (xi, 339 pages) Series The Luther H. Hodges Jr. and Luther H. Hodges Sr. series on business, entrepreneurship, and public policy Luther H. Hodges, Jr. and Luther H. Hodges, Sr. series on business, entrepreneurship, and public policy. Contents Introduction: How Did We Reach This Point? -- Why Regulate Medicines? -- Trials and Tribulations -- Dreams of Greatness: The Birth of the Pharmaceutical Industry -- Triumph and Tragedy -- Ivory Tower of Power -- The DNA of Biotechnology -- Blockbusters and Bombs: Pressures on the Pharmaceutical Industry -- Sea Monsters, Immunauts, and Death Panels -- Drama on the I-270 Tech Corridor -- Autophagy -- Three Views of a Train Wreck -- Bridging the Valley Summary The introduction of new medicines has dramatically improved the quantity and quality of individual and public health while contributing trillions of dollars to the global economy. In spite of these past successes -- and indeed because of them -- our ability to deliver new medicines may be quickly coming to an end. Moving from the beginning of the twentieth century to the present, A Prescription for Change reveals how changing business strategies combined with scientific hubris have altered the way new medicines are discovered, with dire implications for both health and the economy. To explain how we have arrived at this pivotal moment, Michael Kinch recounts the history of pharmaceutical and biotechnological advances in the twentieth century. Kinch relates stories of the individuals and organizations that built the modern infrastructure that supports the development of innovative new medicines. He shows that an accelerating cycle of acquisition and downsizing is cannibalizing that infrastructure Kinch demonstrates the dismantling of the pharmaceutical and biotechnological research and development enterprises could also provide opportunities to innovate new models that sustain and expand the introduction of newer and better breakthrough medicines in the years to come. - Publisher Bibliography Includes bibliographical references and index Notes Print version record Subject Drug development. Drugs -- Research -- Economic aspects Pharmaceutical industry Drugs -- Design. Drug Design Drug Industry MEDICAL -- Pharmacology. BUSINESS & ECONOMICS -- Development -- Business Development. Drugs -- Design Drug development Drugs -- Research -- Economic aspects Pharmaceutical industry Form Electronic book ISBN 1469630648 9781469630649 9781469630632 146963063X

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