| Description |
1 online resource (582 pages) : illustrations |
| Series |
ENVIROnetBASE
|
|
BIOSCIENCEnetBASE
|
| Contents |
Front Cover; Editors; Contributors; Contents; 1. Overview and future of molecular biomarkers of exposure and early disease in environmental health; 2. Ethical and legal considerations in biological markers research; 3. Scientific and policy issues affecting the future of environmental health sciences; 4. Ecogenetics: genetic susceptibility to environmental adversity; 5. Toxicogenomics and pharmacogenomics: basic principles, potential applications, and issues; 6. Individual susceptibility to exposures: a role for genetic variation in DNA repair genes |
|
7. Studies of DNA repair and human cancer: an update8. DNA adducts as biomarkers of DNA damage in lung cancer; 9. Tamoxifen-DNA adducts: biomarkers for drug-induced endometrial cancer; 10. Polycyclic aromatic hydrocarbon DNA adducts and human cancer; 11. Quantitative PCR: a sensitive biomarker of gene-specific DNA damage and repair; 12. Fidelity of DNA synthesis as a molecular biomarker; 13. Mutational specificity of environmental carcinogens |
|
14. Learning-induced modulation of neural cell adhesion molecule polysialylation state as a biomarker of prior inorganic lead exposure during the early postnatal period15. Molecular biomarkers for mercury; 16. Validity of mercury exposure biomarkers; 17. Urinary arsenic species in relation to drinking water, toenail arsenic concentrations and genetic polymorphisms in GSTM1 in New Hampshire; 18. Molecular responses of mammalian cells to nickel and chromate exposure; 19. Chromium: exposure, toxicity, and biomonitoring approaches |
|
20. Using plankton food web variables as indicators for the accumulation of toxic metals in fish21. Validation of exposure and risk biomarkers: aflatoxin as a case study; 22. Biomarkers of early effect in the study of cancer risk; 23. Proteomics in toxicology: an experience with gentamicin; 24. Xenopus laevis genomic biomarkers for environmental toxicology studies; 25. Molecular biomarkers targeting signal transduction systems: the AH receptor pathway; 26. Measuring oxidative damage caused by environmental stressors: potential for reversal and abatement |
|
27. Biomarkers of male reproductive health28. Peripheral benzodiazepine receptors: molecular biomarkers of neurotoxicity; 29. Biomarkers of organ injury from chemical exposure: concurrent inflammation as a determinant of susceptibility; 30. Modulation of GAP junctional communication by "epigenetic" toxicants: a shared mechanism in teratogenesis, carcinogenesis, atherogenesis, immunomodulation, reproductive- and neurotoxicities; 31. Exposure to POPs and other congeners; 32. Polybrominated diphenyl ethers: route, dose, and kinetics of exposure to humans |
| Summary |
OVERVIEWOverview and Future of Molecular Biomarkers of Exposure and Early Disease in Environmental Health, William A. Suk and Samuel H. Wilson Ethical and Legal Considerations in Biological Markers Research, Richard Sharp and Paul ZigasScientific and Policy Issues Affecting the Future of Environmental Health Sciences, Bernard GoldsteinGENOMICS-BASED BIOMARKERS/GENETIC TOXICOLOGY BIOMARKERSEcogenetics: Genetic Susceptibility to Environmental Adversity, Dan NebertToxicogenomics and Pharmacogenomics: Basic Principles, Potential Applications, and Issues, Peter GuengerichIndividual Susceptibility t |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Environmentally induced diseases -- Diagnosis
|
|
Environmentally induced diseases -- Molecular aspects
|
|
Biochemical markers.
|
|
Tumor markers.
|
|
Biomarkers
|
|
Environmental Exposure -- analysis
|
|
Molecular Biology -- methods
|
|
Biomarkers, Tumor
|
|
MEDICAL -- Infectious Diseases.
|
|
HEALTH & FITNESS -- Diseases -- Contagious.
|
|
Biochemical markers
|
|
Tumor markers
|
| Form |
Electronic book
|
| Author |
Wilson, Samuel H., 1939-2021
|
|
Suk, William A. (William Alfred)
|
| ISBN |
9781420032208 |
|
1420032208 |
|
