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Book Cover
Streaming video
Author Maquat, Lynne, speaker

Title Nonsense-mediated and Staufen1-mediated mRNA decay : related pathways of post-transcriptional control in mammalian cells / Lynne E. Maquat
Published London : Henry Stewart Talks, 2007
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (40 min.) : color, sound)
Series From DNA to proteins : the multiple levels of regulation, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation
Contents Contents: Three core Upf NMD factors -- Exon junction complexes (EJCs) -- Upf1 -- Mechanism of NMD -- Activation of EJC-bound Upf1 -- Role of NMD in downregulating spliced mRNAs to eliminate truncated proteins -- NMD downregulating functional protein isoforms -- Restriction to newly synthesized mRNAs during a pioneer round of translation -- Cap Binding Protein (CBP) heterodimer CBP80-CBP20 -- Eukaryotic translation initiation factor (eIF) 4E and steady state mRNA -- Role of CBP80 in enhancing efficiency of NMD by promoting the interaction of Upf1 with EJC-bound Upf2 -- Staufen (Stau)1-mediated mRNA decay (SMD) -- Double-stranded RNA binding protein Stau1 -- Mechanism of action of SMD
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Cellular control mechanisms.
Genetic regulation.
Messenger RNA.
RNA stability
Cytoskeletal Proteins -- physiology.
Eukaryotic Initiation Factors -- metabolism.
Nonsense Mediated mRNA Decay.
Protein Isoforms.
RNA Cap-Binding Proteins.
RNA Processing, Post-Transcriptional.
RNA Splicing.
RNA Stability.
RNA, Double-Stranded.
RNA, Messenger.
RNA-Binding Proteins.
Genre/Form Video recordings.
Form Streaming video
Other Titles Nonsense-mediated and Staufen1-mediated messenger RNA decay : related pathways of post-transcriptional control in mammalian cells
RNA surveillance