| Description |
1 online resource (1 streaming video file (40 min.) : color, sound) |
| Series |
From DNA to proteins : the multiple levels of regulation, 2056-452X |
|
Henry Stewart talks. Biomedical & life sciences collection. From DNA to proteins : the multiple levels of regulation
|
| Contents |
Contents: Three core Upf NMD factors -- Exon junction complexes (EJCs) -- Upf1 -- Mechanism of NMD -- Activation of EJC-bound Upf1 -- Role of NMD in downregulating spliced mRNAs to eliminate truncated proteins -- NMD downregulating functional protein isoforms -- Restriction to newly synthesized mRNAs during a pioneer round of translation -- Cap Binding Protein (CBP) heterodimer CBP80-CBP20 -- Eukaryotic translation initiation factor (eIF) 4E and steady state mRNA -- Role of CBP80 in enhancing efficiency of NMD by promoting the interaction of Upf1 with EJC-bound Upf2 -- Staufen (Stau)1-mediated mRNA decay (SMD) -- Double-stranded RNA binding protein Stau1 -- Mechanism of action of SMD |
| Notes |
Animated audio-visual presentation with synchronized narration |
|
Title from title frames |
|
Mode of access: World Wide Web |
|
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+ |
| Subject |
Cellular control mechanisms.
|
|
Genetic regulation.
|
|
Messenger RNA.
|
|
RNA stability
|
|
Cytoskeletal Proteins -- physiology.
|
|
Eukaryotic Initiation Factors -- metabolism.
|
|
Exons.
|
|
Nonsense Mediated mRNA Decay.
|
|
Protein Isoforms.
|
|
RNA Cap-Binding Proteins.
|
|
RNA Processing, Post-Transcriptional.
|
|
RNA Splicing.
|
|
RNA Stability.
|
|
RNA, Double-Stranded.
|
|
RNA, Messenger.
|
|
RNA-Binding Proteins.
|
| Genre/Form |
Video recordings.
|
| Form |
Streaming video
|
|
