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Factor NF-kB, Transcription -- See NF-kappa B


Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA
  1
 

Factor, NFATC1 Transcription -- See NFATC Transcription Factors


A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2
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Factor, NFATC2 Transcription -- See NFATC Transcription Factors


A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2
  1
 

Factor, NFATC3 Transcription -- See NFATC Transcription Factors


A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2
  1
 

Factor of safety -- See Safety factor in engineering


  1
 

Factor, Phosphodiesterase Activating -- See Calmodulin


A heat-stable, low-molecular-weight activator protein found mainly in the brain and heart. The binding of calcium ions to this protein allows this protein to bind to cyclic nucleotide phosphodiesterases and to adenyl cyclase with subsequent activation. Thereby this protein modulates cyclic AMP and cyclic GMP levels
  1
 

Factor, Platelet Activating -- See Platelet Activating Factor


A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION
  1
 

Factor, Platelet-Derived Growth -- See Platelet-Derived Growth Factor


Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication
  1
 

Factor, Political -- See Politics


Activities concerned with governmental policies, functions, etc
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Factor, Precipitating -- See Precipitating Factors


Factors associated with the definitive onset of a disease, illness, accident, behavioral response, or course of action. Usually one factor is more important or more obviously recognizable than others, if several are involved, and one may often be regarded as "necessary". Examples include exposure to specific disease; amount or level of an infectious organism, drug, or noxious agent, etc
  1
 

Factor, Predisposing -- See Causality


The relating of causes to the effects they produce. Causes are termed necessary when they must always precede an effect and sufficient when they initiate or produce an effect. Any of several factors may be associated with the potential disease causation or outcome, including predisposing factors, enabling factors, precipitating factors, reinforcing factors, and risk factors
  1
 

Factor, Prognostic -- See Prognosis


A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations
  1
Factor proportions.   2
Factor proportions -- Developing countries : The science of economic development and growth : the theory of factor proportions / Clement C. Onyemelukwe  2016 1
Factor proportions -- Mathematical models. : The scarce-factor propositions : summary and generalization / Paul van Moeseke  1987 1
 

Factor, Protective -- See Protective Factors


An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with prevention or mitigation of a health-related condition considered important to prevent
  1
 

Factor, Psychological -- See Psychology


The science dealing with the study of mental processes and behavior in man and animals
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Factor, Psychosocial -- See Psychology


The science dealing with the study of mental processes and behavior in man and animals
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Factor Receptor, Trophic -- See Receptors, Growth Factor


Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells
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Factor, Reinforcing -- See Causality


The relating of causes to the effects they produce. Causes are termed necessary when they must always precede an effect and sufficient when they initiate or produce an effect. Any of several factors may be associated with the potential disease causation or outcome, including predisposing factors, enabling factors, precipitating factors, reinforcing factors, and risk factors
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Factor, Rho -- See Rho Factor


A protein which effects termination of RNA synthesis during the genetic transcription process by dissociating the ternary transcription complex RNA;-RNA POLYMERASE DNA at the termination of a gene
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Factor, Risk -- See Risk Factors


An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent
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Factor, Sex -- See Sex Factors


Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances
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Factor, Socioeconomic -- See Socioeconomic Factors


Social and economic factors that characterize the individual or group within the social structure
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Factor, Sociological -- See Sociological Factors


Attributes and experiences that influence an individual's personality, attitudes, and lifestyle, which are derived from the social values and/or behavior of the groups to which an individual belongs, or aspires to belong
  1
 

Factor, Sulfation -- See Somatomedins


Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism
  1
Factor tables.   2
 

Factor Thirteen -- See Factor XIII


A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade
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Factor, Time -- See Time Factors


Elements of limited time intervals, contributing to particular results or situations
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Factor, Transcription -- See Transcription Factors


Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process
  1
 

Factor, Tumor Angiogenic -- See Angiogenesis Inducing Agents


Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS
  1
Factor V -- genetics. : Factor VIII and Haemophilia A / Geoffrey Kemball-Cook  2016 1
Factor VII -- chemistry. : Tissue factor and factor VII : initiation of blood coagulation / John H. McVey  2007 1
Factor VII -- metabolism. : Tissue factor and factor VII : initiation of blood coagulation / John H. McVey  2007 1
Factor VIIa -- history. : Treating life-threatening bleedings : development of recombinant coagulation factor VIIa / Ulla K.E. Hedner  2017 1
Factor VIII   2
Factor VIII -- antagonists & inhibitors. : Inhibitors in patients with haemophilia / edited by E.C. Rodriguez-Merchan, C.A. Lee  2002 1
 

Factor VIII (Blood coagulation) -- See Blood coagulation factor VIII


  1
  Factor VIII deficiency -- 2 Related Subjects   2
 

Factor VIII Deficiency, Congenital -- See Hemophilia A


The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage
  1
Factor VIII -- genetics. : Factor VIII and Haemophilia A / Geoffrey Kemball-Cook  2016 1
Factor VIII -- physiology.   3
 

Factor VIIIa deficiency -- See Hemophilia A


The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage
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Factor XI. : The physiology and pathology of coagulation factor XI / David Gailani  2007 1
Factor XI -- antagonists & inhibitors. : Inhibitors in patients with haemophilia / edited by E.C. Rodriguez-Merchan, C.A. Lee  2002 1
 

Factor XI, Coagulation -- See Factor XI


Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C
  1
 

Factor XI Deficiencies -- See Factor XI Deficiency


A hereditary deficiency of blood coagulation factor XI (also known as plasma thromboplastin antecedent or PTA or antihemophilic factor C) resulting in a systemic blood-clotting defect called hemophilia C or Rosenthal's syndrome, that may resemble classical hemophilia
  1
 

Factor XI Deficiency -- See Also Factor XI


Stable blood coagulation factor involved in the intrinsic pathway. The activated form XIa activates factor IX to IXa. Deficiency of factor XI is often called hemophilia C
  1
Factor XI Deficiency. : The physiology and pathology of coagulation factor XI / David Gailani  2007 1
Factor XI -- physiology. : The physiology and pathology of coagulation factor XI / David Gailani  2007 1
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