Title The G protein-coupled receptors handbook / edited by Lakshmi A. Devi ; foreword by Andreas Engel, Krzysztof Palczewski

Published Totowa, N.J. : Humana Press, ©2005

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Description 1 online resource (xv, 412 pages) : illustrations Series Contemporary clinical neuroscience Contemporary clinical neuroscience. Contents GPCRs: Structure and Function -- Structure--Function Relationships in G Protein-Coupled Receptors -- Molecular Mechanisms Involved in the Activation of Rhodopsin-Like Seven-Transmembrane Receptors -- GPCR Folding and Maturation -- Regulated Membrane Trafficking and Proteolysis of GPCRs -- GPCR Activity and Its Regulators -- Heterotrimeric G Proteins and Their Effector Pathways -- RGS Proteins -- G Protein-Coupled Receptor Kinases -- Regulators of GPCR Activity -- GPCR Interacting Proteins -- GPCR Dimerization/Oligomerization -- Biophysical and Biochemical Methods to Study GPCR Oligomerization -- Oligomerization Domains of G Protein-Coupled Receptors -- Functional Complementation and the Analysis of GPCR Dimerization -- The Role of Oligomerization in G Protein-Coupled Receptor Maturation -- Receptor Oligomerization and Trafficking -- Modulation of Receptor Pharmacology by G Protein-Coupled Receptor Dimerization -- Recent Developments in Drug Discovery -- Role of Heteromeric GPCR Interactions in Pain/Analgesia -- Conformational Plasticity of GPCR Binding Sites -- De-Orphanizing GPCRs and Drug Development Summary "The G Protein-Coupled Receptors Handbook offers pharmacologists, biochemists, and neuroscientists an exhaustive review of the progress made in understanding how GPCRs are activated and regulated, key factors in exploiting GPCRs for drug development."--Jacket Bibliography Includes bibliographical references and index In OhioLINK electronic book center SpringerLink Subject G proteins -- Receptors -- Handbooks, manuals, etc G proteins. G proteins -- Receptors Receptors, G-Protein-Coupled GTP-Binding Proteins MEDICAL -- Histology. Biomédecine. Sciences de la vie. G proteins G proteins -- Receptors Genre/Form Electronic books handbooks. Handbooks and manuals Handbooks and manuals. Guides et manuels. Form Electronic book Author Devi, Lakshmi A. LC no. 2004024043 ISBN 1588293653 9781588293657 9781592599196 1592599192

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