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Book Cover
Streaming video
Author Schapira, Anthony H. V. (Anthony Henry Vernon), speaker

Title Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease / A.H.V. Schapira
Published London : Henry Stewart Talks, 2014
Online access available from:
HSTalks Biomedical & Life Sciences Collection    View Resource Record  


Description 1 online resource (1 streaming video file (35 min.) : color, sound)
Series Parkinson's disease, 2056-452X
Henry Stewart talks. Biomedical & life sciences collection. Parkinson's disease
Contents Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies
Notes Animated audio-visual presentation with synchronized narration
Title from title frames
Mode of access: World Wide Web
System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Subject Lysosomes -- Metabolism.
Mitochondrial pathology.
Parkinson's disease -- Pathogenesis.
DNA, Mitochondrial.
Gaucher Disease.
Lysosomes -- metabolism.
Lysosomes -- pathology.
Mitochondria -- metabolism.
Mitochondria -- pathology.
Mitochondrial Degradation.
Mitochondrial Diseases.
Parkinson Disease -- metabolism.
Parkinson Disease -- pathology.
Parkinson Disease -- physiopathology.
Genre/Form Video recordings.
Form Streaming video