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Title 25 years of p53 research / edited by Pierre Hainaut and Klas G. Wiman
Published Dordrecht : Springer, [2005]
Online access available from:
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Description 1 online resource (xi, 446 pages) : illustrations (some color)
Contents The First Twenty-Five Years of p53 Research -- Regulation of p53 DNA Binding -- 20 Years of DNA Damage Signaling to p53 -- Gatekeepers of the Guardian: p53 Regulation by Post-Translational Modification, MDM2 and MDMX -- Regulation of the p53 Response by Cellular Growth and Survival Factors -- P53, Cell Cycle Arrest and Apoptosis -- P53 Has a Direct Pro-apoptotic Action at the Mitochondria -- Manipulating the p53 Gene in the Mouse: Organismal Functions of a Prototype Tumor Suppressor -- P53, P63, and P73: Internecine Relations? -- P73, P63 and Mutant P53: Members of Protein Complexs Floating in Cancer Cells -- P53: Gatekeeper, Caretaker or Both? -- Analysis of p53 Gene Alterations in Cancer: A Critical View -- Patterns of TP53 Mutations in Human Cancer: Interplay Between Mutagenesis, DNA Repair and Selection -- Prognostic and Predictive Value of TP53 Mutations in Human Cancer -- P53 Links Tumor Development to Cancer Therapy -- Novel p53-Based Therapies: Strategies and Future Prospects -- Wild Type p53 Conformation, Structural Consequences of p53 Mutations and Mechanisms of Mutant p53 Rescue -- Mutant p53 Reactivation as a Novel Strategy for Cancer Therapy -- Novel Approaches to p53-Based Therapy: ONYX-015 -- p53 as Seen by an Outsider
Summary "This book, written by world-leading p53 researchers, many of whom have shaped the field over the past 25 years, provides unique insights into the progress of the p53 field and the prospects for better cancer diagnosis and therapy in the future. It should be of interest to everybody working in cancer research, clinical oncology, and molecular biology, and indeed to anybody interested in science, medicine, as well as in recent developments of the ideas and concepts of the molecular biology of cancer."--Jacket
Bibliography Includes bibliographical references and index
Notes Print version record
Subject p53 antioncogene.
Genes, p53 -- physiology.
Research -- trends.
Tumor Suppressor Protein p53 -- physiology.
Form Electronic book
Author Hainaut, Pierre.
Wiman, Klas.
LC no. 2005299496
ISBN 1402029209
Other Titles Twenty-five years of p53 research