| Description |
1 online resource |
| Contents |
Front Cover; Conquering RAS: From Biology to Cancer Therapy; Conquering RAS: From Biology to Cancer Therapy; Copyright; Dedication; Contents; List of Contributors; Acknowledgments; Introduction; 01 -- RAS Cancer Biology ; 1 -- Ras and RASSF Effector Proteins ; INTRODUCTION; The RASSF Family of Proteins; RAS AND RASSF1; RAS AND RASSF5 (NORE1); RAS AND RASSF2; RAS AND RASSF3; RAS AND RASSF4 (AD037); RAS AND RASSF6; EFFECTS OF RASSF PROTEINS ON MITOGENIC RAS EFFECTORS; THERAPEUTIC RAMIFICATIONS; CONCLUSION; GLOSSARY; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES |
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2 -- Ras and the Hippo Pathway in Cancer INTRODUCTION; THE HIPPO TUMOR SUPPRESSOR PATHWAY; MST AND LATS AS THE CENTRAL MAMMALIAN KINASES UNDER THE INFLUENCE OF HIPPO SIGNALING; YAP SIGNALING AND ITS REGULATION BY HIPPO; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES; 3 -- The Many Roles of Ral GTPases in Ras-Driven Cancer ; INTRODUCTION; RAL REGULATION; RalGEFs; RalGAPs; Localization; RAL EFFECTORS; RalBP1; Exocyst; Additional Effectors; RAL IN MODEL SYSTEMS; RAL IN TUMORIGENESIS; INHIBITION OF RAL; CONCLUSIONS AND FUTURE DIRECTIONS; REFERENCES |
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4 -- The Biology, Prognostic Relevance, and Targeted Treatment of Ras Pathway-Positive Childhood Acute Lymphoblastic Leukemia INTRODUCTION; CHILDHOOD ALL; RAS PATHWAY ACTIVATION; ARE RAS PATHWAY MUTATIONS AN INITIATING OR SECONDARY EVENT?; DISEASE EVOLUTION; PROGNOSTIC SIGNIFICANCE; TARGETED THERAPIES; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 5 -- Oncogenic KRAS and the Inflammatory Micro-Environment in Pancreatic Cancer ; ONCOGENIC KRAS DRIVES PANCREATIC CANCER DEVELOPMENT; THE IMPORTANCE OF INFLAMMATION IN PDAC DEVELOPMENT |
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INTER-RELATION BETWEEN ONCOGENIC KRAS AND INFLAMMATION IN PANCREATIC CANCEROncogenic Kras Induces Inflammatory Pathways in Pancreatic Cancer; Inflammation Reciprocally Promotes Kras Over-activation; OBESITY-RELATED INFLAMMATION PROMOTES PANCREATIC CANCER DEVELOPMENT; POTENTIAL TARGETS FOR INTERVENTIONS; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; REFERENCES; 6 -- Activation of Ras by Post-Translational Modifications ; INTRODUCTION; POST-TRANSLATIONAL MODIFICATIONS OF RAS; Prenylation; The CAAX Processing; The Enzymes for Prenylation; Farnesyltransferase; Geranylgeranyltransferase Type I |
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Ras Converting Enzyme 1Isoprenylcysteine Carboxyl Methyltransferase; Targeting Ras Prenylation; Palmitoylation and De-palmitoylation Cycle; Phosphorylation; Ubiquitination; Acetylation; S-Nitrosylation; Bacterial Toxins and Exoenzymes; CONCLUSIONS; LIST OF ACRONYMS AND ABBREVIATIONS; ACKNOWLEDGMENT; REFERENCES; 7 -- Cross Talk Between Snail and Mutant K-Ras Contributes to Pancreatic Cancer Progression ; INTRODUCTION; K-RAS AND PANCREATIC CANCER PROGRESSION; EPITHELIAL-TO-MESENCHYMAL TRANSITION AND PANCREATIC CANCER PROGRESSION |
| Summary |
Conquering RAS: From Biology to Cancer Therapy provides introductory knowledge on how modern RAS biology is taking shape in light of newer technological development. Each chapter is written in a manner that emphasizes simplicity and readability for both new investigators and established researchers. While RAS biology has been intensively studied for more than three decades, we are yet to see any effective therapeutics that could interfere in the signaling cascade regulated by this master oncogene. The book covers topics ranging from basic RAS biology, to translational biology and drug discovery applications. These topics will be appealing to basic researchers working in labs who seek deeper understanding of the modern concepts in RAS research. On the other side, the oncologist at the patient's bedside will find the book useful as they routinely face the daunting task of treating patients that predominantly have a disease driven by oncogenic KRAS. Brings together wide ranging topics in RAS basic and translational biology for the scientific and clinical communities. Showcases recent advancements in RAS research under one comprehensive volume. Includes video clips, color illustrations, and important website links to facilitate a clear understanding of RAS in cancer research |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Online resource; title from PDF title page (EBSCO, viewed August 23, 2016) |
| Subject |
Ras oncogenes.
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Genes, ras
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HEALTH & FITNESS -- Diseases -- General.
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MEDICAL -- Clinical Medicine.
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MEDICAL -- Diseases.
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MEDICAL -- Evidence-Based Medicine.
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MEDICAL -- Internal Medicine.
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Ras oncogenes
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| Form |
Electronic book
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| ISBN |
9780128035412 |
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0128035412 |
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