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Mark   Year Entries
Genes, p53.   6
Genes, p53 -- genetics. : DNA research, genetics, and cell biology / editor, Tsisana Shartava  2011 1
Genes, p53 -- physiology. : 25 years of p53 research / edited by Pierre Hainaut and Klas G. Wiman  2005 1
Genes -- Patents.   7
Genes -- Periodicals   7
Genes -- Philosophy.   2
Genes -- physiology.   5
 

Genes, Plant -- See Also Genome, Plant


The genetic complement of a plant (PLANTS) as represented in its DNA
  1
Genes, Plant.   2
 

Genes, Pleiotropic -- See Genetic Pleiotropy


A phenomenon in which multiple and diverse phenotypic outcomes are influenced by a single gene (or single gene product.)
  1
Genes -- Popular works. : The language of the genes : biology, history and the evolutionary future / Steve Jones  1994 1
  Genes, ras -- 2 Related Subjects   2
Genes, ras.   2
 

Genes, Regulator -- See Also Transcriptional Activation


Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes
  1
 

Genes, Reiterated -- See Multigene Family


A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
  1
Genes, Reporter. : Molecular imaging with reporter genes / edited by Sanjiv Sam Gambhir, Shahriar S. Yaghoubi  2010 1
Genes, Reporter -- genetics. : Bacterial sensors : synthetic design and application principles / Jan Roelof van der Meer  2011 1
Genes -- Research -- History. : Proteins, enzymes, genes : the interplay of chemistry and biology / Joseph S. Fruton  1999 1
Genes -- Research -- Periodicals : DNA research (Online)    1
 

Genes, Retinoblastoma -- See Also Retinoblastoma


A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
  1
Genes, Retinoblastoma -- physiology. : Rb and tumorigenesis / [edited by] Maurizio Fanciulli  2006 1
 

Genes, Selfish -- See Repetitive Sequences, Nucleic Acid


Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES)
  1
Genes -- Social aspects.   2
 

Genes, Spliced -- See DNA, Recombinant


Biologically active DNA which has been formed by the in vitro joining of segments of DNA from different sources. It includes the recombination joint or edge of a heteroduplex region where two recombining DNA molecules are connected
  1
Genes, src. : Three decades of protein phosphorylation and cancer : the identification and characterization of the src gene product / Raymond L. Erikson  2010 1
 

Genes, sry -- See Also Sex Determination Processes


The mechanisms by which the SEX of an individual's GONADS are fixed
  1
Genes, Switch.   2
Genes, Synthetic. : Population modification of malaria vector mosquitoes / Anthony A. James  2018 1
 

Genes, T-Cell Receptor -- See Also Receptors, Antigen, T-Cell


Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains
  1
Genes, T-Cell Receptor. : The T cell receptor factsbook / Marie-Paule Lefranc, GĂ©rard Lefranc  2001 1
 

Genes, T-Cell Receptor delta -- See Also Receptors, Antigen, T-Cell, gamma-delta


T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3)
  1
Genes, T-Cell Receptor delta. : Gamma-delta T cells / volume editors, Paul R. Bergstresser, A. Takashima  2001 1
 

Genes, T-Cell Receptor gamma -- See Also Receptors, Antigen, T-Cell, gamma-delta


T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3)
  1
Genes, T-Cell Receptor gamma. : Gamma-delta T cells / volume editors, Paul R. Bergstresser, A. Takashima  2001 1
 

Genes, TcR -- See Genes, T-Cell Receptor


DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. The TcR genes are formed by somatic rearrangement (see GENE REARRANGEMENT, T-LYMPHOCYTE and its children) of germline gene segments, and resemble Ig genes in their mechanisms of diversity generation and expression
  1
 

Genes, TcR delta -- See Genes, T-Cell Receptor delta


DNA sequences encoding the delta chain of the T-cell receptor. The delta-chain locus is located entirely within the alpha-chain locus
  1
 

Genes, TcR gamma -- See Genes, T-Cell Receptor gamma


DNA sequences encoding the gamma chain of the T-cell receptor. The human gamma-chain locus is organized similarly to the TcR beta-chain locus
  1
 

Genes, TP53 -- See Genes, p53


Tumor suppressor genes located on the short arm of human chromosome 17 and coding for the phosphoprotein p53
  1
 

Genes, Transforming -- See Oncogenes


Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene
  1
  Genes, Transgenic, Suicide -- 2 Related Subjects   2
 

Genes, Tumor Suppressing -- See Genes, Tumor Suppressor


Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible
  1
 

Genes, Tumor Suppressor -- See Also Tumor Suppressor Proteins


Proteins that are normally involved in holding cellular growth in check. Deficiencies or abnormalities in these proteins may lead to unregulated cell growth and tumor development
  1
Genes, Tumor Suppressor.   7
 

Genes, v-Ha-ras -- See Genes, ras


Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein
  1
 

Genes, v-Ki-ras -- See Genes, ras


Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein
  1
 

Genes, v-myc -- See Genes, myc


Family of retrovirus-associated DNA sequences (myc) originally isolated from an avian myelocytomatosis virus. The proto-oncogene myc (c-myc) codes for a nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Truncation of the first exon, which appears to regulate c-myc expression, is crucial for tumorigenicity. The human c-myc gene is located at 8q24 on the long arm of chromosome 8
  1
 

Genes, v-src -- See Genes, src


Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20
  1
  Genes, Viral -- 4 Related Subjects   4
Genes, Viral.   3
Genes, Viral -- genetics. : Viral vectors : gene therapy and neuroscience applications / edited by Michael G. Kaplitt, Arthur D. Loewy  1995 1
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