| Description |
1 online resource |
| Contents |
Cover -- Title -- Copyright -- Contents -- List of Contributors -- Foreword -- Introduction -- Chapter 1 -- Evolution of LH and FSH from a common gonadotropic ancestral hormone -- References -- Chapter 2 -- Evolution of CG and development of humans -- References -- Chapter 3 -- Structure of FSH -- References -- Chapter 4 -- Structure of LH -- References -- Chapter 5 -- Structure of hCG -- References -- Chapter 6 -- Structure of multiple forms of hCG -- References -- Chapter 7 -- Synthesis of the gonadotropins -- References -- Chapter 8 -- Function of gonadotropin releasing hormone and inhibin -- Gonadotropin releasing hormone -- Neuroanatomy -- GnRH structure -- GnRH secretion -- Control/regulation of GnRH -- Regulation of GnRH by neuronal inputs -- KNDy neurons -- Other neuropeptides -- Regulation of GnRH by gonadal feedback -- Regulation of GnRH by other regulating factors -- Clinical application of GnRH -- GnRH in the ovary -- GnRH in the endometrium -- Inhibin -- Structure -- Receptors -- Production and inhibin expression in females -- Production and expression in males -- Summary -- References -- Chapter 9 -- Function of hormone hCG -- Synthesis and maintenance of hemochorial placentation -- Progesterone production by corpus luteum -- Suppression of myometrial contractions during pregnancy -- Suppression of maternal macrophages during pregnancy -- Controlling blastocyst implantation -- hCG role preimplantation preparation of the endometrium -- New observations -- Fetal hCG and fetal organs -- References -- Chapter 10 -- Function of hyperglycosylated hCG and extravillous cytotrophoblast hCG -- References -- Chapter 11 -- Degradation of hCG -- References -- Chapter 12 -- Gonadotropin immunoassays: antibodies and standards for hCG, LH, and FSH -- Reference -- Chapter 13 -- Genetics of the gonadotropins -- Genetics of FSH |
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Genetics of the hCG/LH gene cluster -- References -- Chapter 14 -- Gonadotropins and steroidogenesis -- Estrogens and progestogens -- Sex steroid synthesis by the ovary -- Sex steroid synthesis in pregnancy -- Functions of sex steroids -- Sex steroid functions in the menstrual cycle and pregnancy -- Male steroidogenesis -- Functions of androgens in males -- Functions of estrogens males -- Further reading -- Chapter 15 -- Gonadotropins and female reproduction -- Follicular maturation and selection -- Ovulation and luteinization -- Meiosis -- Preparation of the follicle for ovulation -- Ovulation -- Luteinization -- Propulsion of oocyte in the fallopian tube -- Fertilization -- Morula and blastocyst formation -- Twins and multiple pregnancies -- References -- Further reading -- Chapter 16 -- Male reproduction: sperm formation and activation -- Spermatogenesis 1: mitotic proliferation -- Spermatogenesis 2: meiotic division -- Spermatogenesis 3: cytodifferentiation and packaging of sperm cells -- Endocrine control of spermatogenesis -- Maturation of spermatozoa -- Seminal fluids -- Sperm activation -- Spermatozoa capacitation -- Acrosome reaction -- References -- Chapter 17 -- Adrenarche and menarche in girls and adrenarche and puberty in boys -- Adrenarche in girls -- Menarche -- The physiology of starting the menstrual cycle -- Adrenarche in boys -- Puberty in boys -- The physiology of the commencement of puberty -- References -- Chapter 18 -- Function of the luteinizing hormone/chorionic gonadotropin receptor -- Introduction -- LHCGR gene and protein structure -- Physiological functions of LH via the LHCGR -- Signaling pathways -- Signal transduction in the testes -- Signal transduction in the ovary -- Differential signaling by LH and hCG -- Receptor di/oligomers -- Receptor internalization and downregulation -- Mutations and polymorphisms in LHCGR |
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Extragonadal expression of LHCGR -- Concluding remarks -- References -- Chapter 19 -- Function of folllicle stimulating hormone and the follicle stimulating hormone receptor -- Follicle stimulating hormone (FSH) -- Neuroanatomy -- Structure of FSH molecule and FSH receptor -- Control/regulation of FSH -- Regulation of FSH by GnRH -- Regulation of FSH by gonadal feedback -- Regulation of FSH by other regulating factors -- FSH expression from fetal development across the lifespan -- Role of FSH in the menstrual cycle and folliculogenesis -- FSH in spermatogenesis -- Clinical application of FSH -- Chapter summary -- References -- Chapter 20 -- Function of hCG and pregnancy -- References -- Chapter 21 -- Pituitary sulfated hCG -- References -- Chapter 22 -- Hyperglycosylated hCG and extravillous cytotrophoblast hCG -- References -- Chapter 23 -- hCG and pregnancy tests -- References -- Chapter 24 -- False-positive hCG pregnancy tests -- Chapter 25 -- Implantation and pregnancy failure -- References -- Chapter 26 -- Deep implantation, hCG, gestational hypertension, and preeclampsia -- References -- Chapter 27 -- hCG, gestational trophoblastic diseases, and choriocarcinoma -- Hydatidiform mole -- Choriocarcinoma -- References -- Chapter 28 -- Ovarian cystic disorders -- Follicular cyst -- Corpus luteum cyst -- Polycystic ovary syndrome (PCOS) -- Further reading -- Chapter 29 -- Illicit use of hCG in dietary programs and to promote anabolism -- Dietary programs -- hCG and anabolism promotion -- hCG variants as dangerous substances -- References -- Chapter 30 -- Cancer hCG, hyperglycosylated hCG, extravillous cytotrophoblastic hCG and TGFb receptor 2 -- References -- Chapter 31 -- hCG molecules produced in cancer inhibit apoptosis and cell death, a process which can be overturned by specific antibodies: paving a way towards targeted adjuvant cancer immunotherapy |
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Introduction -- Methods -- Materials -- Sheep Antisera Studies -- CDX1307 Study -- Results -- In-House Sheep Antisera -- Early Apoptosis with AnnexinV and P.I. Staining and Cell Cycle FACS Histogram -- CDX1307 Murine Antisera -- Cell Number Assay and Cell Viability Comparison -- CDX1307 Human Antisera -- Cell Number Assay and Cell Viability Comparison -- Cell Cycle and Apoptosis Assay -- Discussion -- Acknowledgments -- References -- Abbreviations -- Index -- Back cover |
| Notes |
Includes index |
|
Print version record |
| Subject |
Gonadotropin.
|
|
Gonadotropins
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Gonadotropin
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| Form |
Electronic book
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| Author |
Butler, Stephen A. (Stephen Andrew)
|
| ISBN |
9780128226322 |
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0128226323 |
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