| Description |
1 online resource (xviii, 518 pages) : illustrations |
| Contents |
Chapter 1 -- Overview of the immune biology of allogeneic hematopoietic stem cell transplantation -- Chapter 2 -- The HLA system in hematopoietic stem cell transplantation -- Chapter 3 -- The impact of minor histocompatibility antigens in allogeneic stem cell transplantation -- Chapter 3 -- The impact of minor histocompatibility antigens in allogeneic stem cell transplantation -- Chapter 5 -- Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans) -- Chapter 5 -- Immune rejection: the immune biology of allogeneic hematopoietic stem cell transplantation (from mice to humans) -- Chapter 7 -- Tumor-associated antigens -- Chapter 8 -- Impact of the conditioning regimen -- Chapter 9 -- Antigen presentation and antigen-presenting cells in graft-versus-host disease -- Chapter 10 -- T-cell costimulation in graft-versus-host disease and graft-versus-leukemia effect -- Chapter 11 -- Th1/Th2 and Tc1/Tc2 cells: biology, experimental models and clinical translation -- Chapter 12 -- Natural CD4+CD25+FOXP3+ regulatory T cells in graft-versus-host disease -- Chapter 13 -- Role of Th17 cells and interleukin 17 in graft-versus-host disease and graft-versus-leukemia reactivity -- Chapter 14 -- B and T cells in chronic graft-versus-host disease and graft-versus-leukemia -- Chapter 15 -- Natural killer cells in graft-versus-host disease and graft-versus-leukemia -- Chapter 16 -- Cytokines in graft-versus-host disease and graft-versus-leukemia -- Chapter 17 -- Chemokines and graft-versus-host disease -- Chapter 18 -- Intracellular sensors of immunity and allogeneic hematopoietic stem cell transplantation -- Statistical considerations -- Chapter 20 -- The endothelium in graft-versus-host disease and graft-versus-leukemia -- Chapter 21 -- Looking toward the future: an individualized approach to allogeneic transplantation |
| Summary |
This book provides clinical and scientific researchers with a deep understanding of the current research and the implications for translational practice. By providing an overview of immune biology of HSCT, an explanation of immune rejection and detail on antigens and their role in HSCT success, this book embraces biologists and clinicians who need a broad view of the deeply complex processes involved. It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia (GVL) effect, and transplantation success. Using illustrative figures, highlighting key issues, describing recent successes and discussing unanswered questions, this book sums up the current state of HSCT to enhance the prospects for the future |
| Bibliography |
Includes bibliographical references and index |
| Notes |
Print version record |
| Subject |
Hematopoietic stem cells -- Transplantation
|
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Blood -- Diseases.
|
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Immunology.
|
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Graft versus host disease.
|
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Hematology.
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Transplantation immunology.
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Hematopoietic Stem Cell Transplantation
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Graft vs Host Disease -- immunology
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Transplantation, Homologous -- immunology
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Transplantation Immunology
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Hematologic Diseases
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Allergy and Immunology
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Graft vs Host Disease
|
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Hematology
|
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MEDICAL -- Research.
|
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Transplantation immunology
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Blood -- Diseases
|
|
Graft versus host disease
|
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Hematology
|
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Hematopoietic stem cells -- Transplantation
|
|
Immunology
|
| Form |
Electronic book
|
| Author |
Socié, Gérard.
|
|
Blazar, Bruce R.
|
| ISBN |
9780123914651 |
|
0123914655 |
|
